10/09/2025
Cats with a "blocked bladder" frequently have elevated serum potassium levels, also known as hyperkalaemia. Why does this occur? Why is it dangerous, and how should we deal with it?
Urinary obstruction in cats frequently results in acute kidney injury. Impaired renal function, combined with a physical blockage in the urethra, prevents potassium from being excreted in urine. These patients may also have metabolic acidosis, which occurs when there is an increase in acids such as hydrogen (H+), and the cells attempt to absorb the H+ to buffer the acidosis, causing potassium, which is normally an intracellular ion, to enter the extracellular space.
So, why is this so dangerous?
Potassium affects the resting membrane potential of myocardial cells in the heart. Serum concentrations greater than 5.5 mmol/l can prolong cell action potential and prevent repolarisation. This can cause bradycardia, peaked T waves, loss of P waves, wide and abnormal QRS complexes, ventricular fibrillation, and even asystole (Monaghan et al., 2012). Any cat with urethral obstruction should have an ECG to monitor for these changes.
Not good, huh? What do we do about it?
The treatment aims to protect the heart and lower serum potassium levels. To begin, relieving urethral obstruction with a urinary catheter will significantly lower potassium levels. But a patient needs to be stable enough to undergo an anaesthetic for this first.
Calcium gluconate is a cardioprotective drug that can be administered; it protects myocardial cells but does not reduce potassium levels. Instead, it stabilises the cardiac cell membrane by lowering the threshold potential from the elevated resting potential.
Intravenous fluid therapy can be used to increase elimination after obstruction removal and to dilute potassium levels in the blood (Jones et al., 2022). Along with this, insulin and dextrose can be administered; insulin causes potassium to return to cells, while dextrose upregulates this system by increasing insulin production (Jones et al., 2022). When using this treatment method, blood glucose levels must be monitored frequently to detect hypoglycaemia.
Let's Get Lit:
- https://pmc.ncbi.nlm.nih.gov/articles/PMC9742918/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC11112173/