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Dr Harris Clinic

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Dr Harris Clinic

Dr Harris is an aesthetic doctor recognised for his scientific approach and natural looking results.

10/04/2026

This patient presented with a sudden onset infraorbital lump at the site of HA filler placed six months earlier.
On examination, the lesion was firm and non-tender.
Clinically, this would be labelled a “delayed onset nodule”.
Ultrasound demonstrated an irregular hypoechoic focus consistent with localised filler.
Complete resolution was achieved with targeted hyaluronidase under ultrasound guidance.
Multiple mechanisms are possible but management should be guided by the most likely underlying process.

08/04/2026

What would you do next?
Leave it
Skin
Refill
Surgery

06/04/2026

The under-eye is one of the most common areas I see for filler modification, second only to lips.
In this area, small amounts of poorly distributed filler can disrupt contour, skin texture and light reflection.
Normalisation before beautification.

03/04/2026

Before (left) → After (right)
Normalisation before beautification

31/03/2026

Hybrid fillers are often presented as combining the “best of both”
But combining mechanisms doesn’t necessarily mean better outcomes
The question isn’t how many mechanisms are involved
It’s whether they translate into meaningful clinical results
At present, there is no consistent evidence of superiority

29/03/2026

“It works at a cellular level” is often used to describe so called aesthetic “regenerative” treatments.
But all biology is cellular.
Inflammation is cellular.
Fibrosis is cellular.
Ageing is cellular.
So the presence of a cellular effect doesn’t tell us whether that effect is beneficial, organised, or clinically meaningful.
The question isn’t whether it acts on cells –
but what are the clinical endpoints?

27/03/2026

Biostimulatory treatments are often described as “collagen stimulating.”
But collagen alone doesn’t define skin function.
Collagen provides strength.
Elastin provides recoil.
Skin quality depends on organisation, elastin integrity and ECM architecture – not just collagen volume.
Remodelling can be adaptive or fibrotic.
More collagen does not necessarily mean better outcomes.
Do you agree?

26/03/2026

Biostimulators, including exosomes and polynucleotides, are often described as “signalling” treatments.
But signalling is not a controlled process.
The same signal can produce different outcomes depending on the biological context.
Changes in collagen or signalling pathways do not necessarily translate into meaningful structural or clinical outcomes.
That’s not the same as regeneration.

23/03/2026

There’s a growing narrative that biostimulators treat the “root cause” of ageing, and HA fillers simply mask it.
But ageing does not have a single cause.
It is a combination of structural and biological changes, including fat compartment deflation, skeletal remodelling, and changes in tissue support and skin.
Different treatments act on different component of this process.
Biostimulation may influence tissue signalling. That is not regeneration.

20/03/2026

Fat transfer is often framed as the “natural” alternative to HA fillers.
But once transplanted, fat is no longer native tissue – it’s a graft.
And graft survival is highly variable.
When fat doesn’t survive, the outcome isn’t “natural” - it can lead to necrosis, oil cyst formation, and persistent inflammatory change.
Even in successful cases, the process is biologically active, not passive.
Systematic reviews report complications including irregularity, prolonged oedema, and fat necrosis – all linked to how the graft behaves in tissue (references in my comment).
“Natural” isn’t a biological category – it’s often used as a marketing shorthand.
The question isn’t whether something is “natural”. It’s how it behaves in tissue.

18/03/2026

There’s a growing trend of dismissing HA fillers as “inflammatory” – often used as shorthand for “harmful”.
But this reflects a misunderstanding of basic biology.
All implanted materials – sutures, implants, even wound healing itself – generate an inflammatory response. That does not make them pathological.
What matters is the nature and behaviour of that response.
On the left (slide 2): organised granulomatous inflammation – a dense, structured inflammatory pattern.
On the right: the typical tissue response to hyaluronic acid – low-grade, dispersed, and generally well tolerated (granulomatous reactions can occur with HA, but they are uncommon and reflect a different inflammatory pattern).
Not all inflammation is pathological.
And not all foreign body responses are harmful.
As a field, we should be careful not to replace evidence with rhetoric – particularly when discussing treatments that millions of patients undergo safely each year.

14/03/2026

Aesthetic conferences are presented as educational meetings.
Yet many talks and panels are funded by the same companies whose products are discussed on stage.
Industry collaboration has helped drive innovation in aesthetics, but it inevitably raises questions about independence.
What do you think – education or marketing?

Address

48 Crouch Hall Road
London
N88HJ

Opening Hours

Monday	10am - 8pm
Tuesday	10am - 7pm
Wednesday	10am - 7pm
Thursday	10am - 7pm
Friday	10am - 7pm

Website

https://harrisclinic.co.uk/

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