21/05/2026
Delighted to share our new publication in epilepsy research: “Vitamin D3 prevents epileptic seizures by modulating the Ras signalling pathway via Gnb1 and Casr in acute epilepsy mouse models.”
This study provides new mechanistic insights into the neuroprotective role of vitamin D3 in acute epilepsy. Using PTZ- and KA-induced mouse models, we found that vitamin D3 reduced seizure activity, alleviated hippocampal neuronal damage, and modulated the Casr–Gnb1–Ras signalling pathway.
These findings suggest that vitamin D3 may have potential as an adjunctive neuroprotective strategy in epilepsy and open new directions for understanding the molecular links between calcium signalling, Ras pathway regulation and seizure-related brain injury.
Congratulations to all co-authors and collaborators on this meaningful contribution to epilepsy research.