12/12/2025
Belly fat
It turns out there’s a biological reason our waistlines tend to grow as we reach middle age. New research shows that aging activates a special group of stem cells that rapidly produce fresh fat cells especially around the abdomen. Scientists from City of Hope and UCLA discovered that normal fat stem cells gradually transform into new ones called CP-As, which are far more active in older bodies. This shift is driven by a signaling pathway called LIFR, which becomes crucial for triggering this age-related fat buildup.
In experiments, researchers transplanted fat stem cells from older mice into younger ones, and the results were striking: the older cells created large amounts of new fat even in a youthful, healthy environment. Meanwhile, young stem cells placed in older mice stayed mostly inactive. This proves that aging changes the stem cells themselves, giving them an enhanced ability to make fat regardless of the body they’re in. When scientists looked at human tissue, they found the same aging-specific fat-producing cells in middle-aged adults.
These findings could open the door to future treatments that block CP-A cells or the LIFR signal, helping people manage stubborn belly fat tied to aging. By targeting these overactive fat-making cells, researchers hope to reduce risks connected to abdominal fat, including metabolic and heart-related issues.