03/08/2024
Question:
A 45-year-old woman presents with a 6-month history of progressive shortness of breath, fatigue, and weight loss. Physical examination reveals:
- Bilateral lung crackles
- Clubbing of fingers
- Enlarged lymph nodes in the neck and axilla
Chest radiograph shows:
- Bilateral hilar lymphadenopathy
- Interstitial infiltrates
Pulmonary function tests reveal:
- Forced vital capacity (FVC): 60% predicted
- Diffusing capacity for carbon monoxide (DLCO): 40% predicted
What is the most likely diagnosis?
A) Sarcoidosis
B)Pulmonary fibrosis
C) Chronic obstructive pulmonary disease (COPD)
D) Pneumonia
Explanation:
The patient's presentation and diagnostic results suggest sarcoidosis, a systemic granulomatous disease that often affects the lungs. The key findings are:
- Bilateral lung crackles and clubbing, indicating pulmonary involvement
- Enlarged lymph nodes in the neck and axilla, suggesting systemic involvement
- Bilateral hilar lymphadenopathy and interstitial infiltrates on chest radiograph, consistent with sarcoidosis
- Reduced FVC and DLCO on pulmonary function tests, indicating restrictive lung disease
Sarcoidosis is the most likely diagnosis, given the combination of pulmonary and extrapulmonary findings.
