12/11/2025
https://www.facebook.com/share/p/17MZje43NG/?mibextid=wwXIfr
My mind was blown at the The UK Adult ADHD Adult Network Conference (www.UKAAN.org) last year when I heard several presentations on the various ADHD’s curious connections to chronic inflammation and dysautonomia.
There is a growing body of research is exploring how a range of physical health conditions affects people with ADHD in previously unknown ways:
Hypermobility, linked to chronic inflammation and dysautonomia (problems with the autonomic nervous system that controls heart rate, blood pressure, and digestion). Research also shows people with ADHD have higher inflammatory markers, and higher inflammation levels are linked to more severe ADHD symptoms. There's also a clear link between ADHD and inflammatory conditions like allergies, asthma, gut issues, and autoimmune disorders.
Mast Cell Activation Syndrome (MCAS) occurs when immune cells overreact to triggers, causing widespread inflammation. Symptoms include flushing, itching, gut problems, fast heart rate, fatigue, and brain fog - plus neuropsychiatric symptoms like anxiety and depression. Antihistamines can lead to dramatic improvements in anxiety, mood, and possibly ADHD symptoms for people with MCAS.
POTS (Postural Orthostatic Tachycardia Syndrome) is a form of dysautonomia where your heart rate spikes when you stand up, causing dizziness and fatigue. Research suggests ADHD and POTS may be closely connected, with POTS patients showing more inattention symptoms.
What you can do:
Consider getting tested if you experience symptoms across multiple body systems
Work with knowledgeable clinicians (allergist, immunologist, or functional medicine practitioner)
Be aware that vitamin D and iron deficiencies are common in ADHD and may contribute to inflammation
Dr James Kustow is a leading expert in this field. He delivered an accessible webinar for@additudemag and they have summarised his work in an article 'ADHD’s Curious Connections to Chronic Inflammation and Dysautonomia'.
(IMAGE CREDIT - abstract graphic from Saccaro, Schilliger, Perroud, & Piguet, 2021).
