22/01/2026
The latest biomarker study to translate promising studies into real-world validated tests to diagnose Alzheimer’s disease was announced this week. It aims to help identify blood or digital tests that could help predict the presence of amyloid plaques or tau tangles in the brain, which are the hallmarks of Alzheimer’s disease.
It is hoped that a simple finger-prick test could be enough to diagnose Alzheimer’s with sufficient accuracy for clinicians to use routinely. The study, led in the UK by Life Arc will involve 1,000 volunteers aged over 60 in the UK, US and Canada.
The new study reflects the growing excitement about the use of blood biomarkers in diagnosis to achieve diagnosis at scale and reduce the cost and time taken for patient testing.
Professor Vanessa Raymont is leading Dementia Platform UK’s own blood biomarker study, READ-OUT. She welcomes the latest new trial.
“This study is an exciting opportunity for the comparison of very accessible markers with more validated markers such as PET imaging. This will definitely help us understand whether the blood biomarkers that look promising really do measure aspects of Alzheimer's disease in real world populations. It will add vital data alongside the Blood Biomarker Challenge funded READ-OUT study, which is looking at these, plus additional blood biomarkers in a UK memory clinic population.”
READ-OUT also focuses on easy-to-do tests, but for a range of dementias including Alzheimer’s, vascular, dementia with Lewy bodies, and frontotemporal dementia. It involves 3,200 participants as part of the Blood Biomarker Challenge funded through the Alzheimer’s Society and Alzheimer’s Research UK including funding from players of the People’s Postcode Lottery. It will assess the best ways of obtaining samples and could lead to the health service using a number of tests taken from a blood sample alongside digital tests of cognition.
https://zurl.co/FvTvg
An international trial involving 1,000 volunteers will aim to detect biomarkers associated with the condition.