Big Data Science in Medicine

12/12/2024

New paper demonstrating intestinal barrier repair function in multiple preclinical models by a novel PHD1/2 inhibitor designed using generative AI to be gut restricted.

Generative artificial intelligence is used to design an effective treatment for inflammatory bowel disease in preclinical models.

08/03/2024

New important paper in AI-powered drug discovery and aging research with experimental validation:

An AI-generated small-molecule inhibitor treats fibrosis in vivo and in phase I clinical trials.

17/08/2023

08/02/2023

Consumer-level Generative AI in medicine should be regulated.

You probably expected me to be the last person to say this since we started presenting on GANs in 2015 and publishing in generative AI since 2016. But when you make generative AI for internal use or B2B applications, the resulting products will need to go through rigorous validation before these products reach the clinic. And businesses will make every effort to validate.
Consumers may self-medicate. And to allow for this, in the short term, we need benchmarking tools, large GPT-friendly biomedical training sets, and some warnings and some level of regulation in the short term.
Once you get addicted to conversational generative AI, you are very likely to trust the systems. And they are very likely to self-medicate.

Here is a brief article outlining these points.

Generative artificial intelligence tools such as chatGPT have many uses in medicine, but a lack of accuracy poses problems.

14/06/2021

Please check out the interview with Joan Mannick, who co-founded resTORbio, and is now heading R&D at David Sinclair's and Nir Barzilai's Life Biosciences. You can see all of them at the 8th Aging Research and Drug Discovery.

In 2014 ResTORbio spun off out of Novartis and went public to try a longevity drug as a vaccine-potentiating agent in the elderly. The company was led by Dr. Joan Mannick, a physician with deep interest in aging. The trial failed in Phase III providing valuable experience, and her work continues.

18/01/2021

A new paper on AI in Longevity Medicine

Recent advances in deep learning enabled the development of AI systems that outperform humans in many tasks and have started to empower scientists and physicians with new tools. In this Comment, we discuss how recent applications of AI to aging research are leading to the emergence of the field of l...

14/09/2020

https://www.nature.com/articles/s41587-020-0686-x

Can traditional computational analysis and machine learning help compensate for inadequate peer review of drug-repurposing papers in the context of an infodemic?

02/07/2020

In September we are launching our full-service AI-powered target discovery platform for industry and academics. You will be able to start unicorn businesses, publish top-tier academic papers, and help solve diseases using your own data, or using the data on the platform. We encourage you to try it out and sign up as a launch partner.

It natively integrates into the upcoming generative chemistry suite that we will open to the maximum of 5 big pharma companies this year.

Our goal is to democratize pharmaceutical R&D, help biologists think like drug hunters, and enable them to produce impactful results.

We are excited to announce that InSilico Medicine will be soon releasing its most advanced OMICs data interpretation and Target ID platform called that is designed to bring a new visual experience to biologists.

Although the official release is planned for September, those interested can get a first glimpse of the product even now.

Please visit https://insilico.com/pandomics

Let us know your thoughts and tell us about the features you would like to see. Any feedback will be very much appreciated!

You can reach us at: pandomics@insilico.com

Alex Zhavoronkov Alexander Aliper Alexey Dubovenko Jan Szollos Ivan Ozerov Regina Lin Jimmy Yen Chu Lin Ola Popova Polina Firsanova

04/09/2019

The new Nature Biotech Paper: Deep learning enables rapid identification of potent DDR1 kinase inhibitors

A machine learning model allows the identification of new small-molecule kinase inhibitors in days.

12/12/2018

https://www.forbes.com/sites/cognitiveworld/2018/12/12/is-life-a-recursive-video-game/

The idea that we humans are living inside a simulation is not new. Many religions propose the existence of a creator—an omnipotent deity who formed the world and set its rules in motion—but this is simply another way of framing the video game hypothesis. It’s bigger than you think...

08/12/2018

Time to revive the B**M series?