26/02/2025
A new Oxford collaborative team of biologists and engineers led by Professor Richard Wade-Martins (DPAG/Kavli), Professor Ed Walsh (Dept. Engineering Sciences) and Dr Ricardo Marquez Gomez (DPAG/Kavli) has been awarded a grant of £2 million from the BBSRC to bring together the technologies of human stem cells and oil-wall microfluidics. The human stem cells will be used to generate each specific neuronal subtype of the cortical-striatal-midbrain circuit held within oil-walled chambers. Such chambers can reliably construct microenvironments and circuits with long-term accessibility, contrasting with current microfluidic technologies based on rigid and single use plastics.
The project will study the physiology, regulation and cellular architecture of neurons in the circuit. Taking advantage of the adaptability properties of the fluid-walls technology, the team will also explore the regulation of gene expression in the cell body and along the neuronal axons which form the circuits to understand how genes control neuronal circuit function.
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