31/01/2026
Let’s explore how histamine, methylation, methyl-b-vitamins and elevated homocysteine can contribute to insomnia. See slides for more context.
Elevated homocysteine can push the brain towards hyper-excitability, weaken inhibitory signalling, and disrupt the neurobiology of sleep.
But it is not a diagnosis, it is a modifiable risk factor. When addressed appropriately, many people notice improvements in sleep quality, greater calm, and improved cognitive resilience.
One important caveat: methylated vitamins do not just “lower homocysteine”.
They increase methyl flux, which directly affects neurotransmitter production and breakdown.
For some brains, that is calming. 🧠
For others, it is overstimulating. 🔥
Histamine plays a role too. It is a wake-promoting neurotransmitter, and its breakdown depends on methylation. Sudden shifts in methylation can destabilise histamine signalling, leading to insomnia, night waking, or a wired-but-tired state.
Lowering homocysteine is not about pushing harder.
It is about balance, context, and the right approach.
A combination of DNA 🧬 and blood 🩸 and urine testing can help with a personalised nutrition and lifestyle approach.