25/02/2026
Fascinating research round up of some gut research which is constantly evolving and challenging what we thought we knew. 💪
I'm a conference addict - always on the lookout for learning more & challenging what I thought I knew, or had nailed! Because that's the beauty of science, it changes… we have to keep an open mind & drive to learn 🤓
I obsessively follow the work of the European Society of Neurogastroenterology & Motility (ESNM) - who provide a dedicated arm called Gut Microbiota for Health (GMFH), focusing on the microbiome's role in health & disease. Their 2025 year in review of published research in this area is brilliant.
Some of the biggest gut microbiome science themes emerging:
❤️ microbiome & cardiovascular risk: A metabolite called imidazole propionate (produced by specific gut bacteria) has been identified as a driver of arterial plaque & a potential early biomarker of cardiometabolic disease. We may soon be able to detect cardiovascular vulnerability before standard markers even flag it. Meanwhile, new mechanistic research is showing how gut microbes directly regulate bile acid production & cholesterol balance
🧠 The gut-brain axis: research is showing that intestinal dendritic cells can physically migrate to the brain & influence behaviour, meaning early-life microbial colonisation may have long-term neurological consequences. New findings are showing the microbiome helps regulate cortisol rhythms & circadian-HPA axis balance…. Literally mind blowing!
🔥 IBD, IBS & precision medicine: Microbiome shifts appear to precede clinical flares in Crohn's disease, opening the door to predictive biomarkers & more personalised treatment. As for IBS? A trial found that many people who believe they react to gluten may actually be responding to FODMAP load / expectation - huge clinical implications!
🧓 Prebiotics for cognitive ageing: A trial for adults over 60 found that an inulin + FOS blend improved cognitive performance versus placebo. The microbiome-brain connection is getting very practical, very fast.
The microbiome is no longer just a digestive story, it's cardiovascular, neurological, immunological, & metabolic - all combined!
This week I'll share practical tools for feeding your microbiome well: fibre, phytochemicals & a challenge you can actually do. Stay tuned.
See the full research finding here: https://f.mtr.cool/qnzczayzxi