20/11/2025
Melissa EO was evaluated for its antioxidant and neuroprotective properties in a preclinical model representing cognitive decline that mimics features of dementia. Melissa EO eased anxiety and significantly improved memory and executive function—the set of mental skills that help us plan, focus, remember, and control our behaviors. Further exploration of its mechanism and molecular targets identified that the EO inhibits AChE activity, helping to preserve that precious "memory chemical" in the brain. Furthermore, it acted as a powerful antioxidant, restoring the body's key defense enzymes and shutting down damaging oxidative stress. Its major constituents, like geranial and neral, showed remarkable ability to cross the blood-brain barrier. This research suggests that melissa EO is a promising multi-targeted solution for neurodegenerative conditions.
Melissa officinalis essential oil (MEO) possesses documented neuroprotective, antioxidant, and anxiolytic properties. This study investigated the effects of MEO (150 and 300 µL/L) in a scopolamine (SCO, 100 µM)-induced zebrafish model of cognitive impairment. Cognitive performance was assessed usi...