25/11/2025
Oestrogen dominance isn’t always about ‘high oestrogen’ - it’s often about imbalance.
When oestrogen rises relative to progesterone in females and testosterone in males, the body can signal through symptoms long before bloodwork is checked.
Common signs include bloating, breast tenderness, sexual dysfunction, PMS, heavy or irregular bleeds, mood swings, headaches, and stubborn weight gain.
But underneath the symptoms is physiology:
• Liver detoxification pathways influence how well oestrogen is broken down and cleared.
• Stress and cortisol can suppress which can lower progesterone, making oestrogen appear ‘dominant’.
• Thyroid dysfunction slows clearance and alters hormone sensitivity.
•Estrobolome disruption (the gut bacteria responsible for oestrogen metabolism) from gut dysbiosis can reactivate oestrogen through the β-glucuronidase pathway, pushing levels higher again.
Our hormone and gut testing helps identify where the imbalance is coming from whether production, metabolism, clearance, or stress-related disruption, so treatment can be personalised, not guessed.
