28/06/2015
HERPES SIMPLEX INFECTION
Herpes simplex is a viral disease caused by the herpes simplex virus
Two types exist:
a) herpes simplex virus type 1 (HSV-1) and
b) type 2 (HSV-2).
Both are closely related but differ in epidemiology. HSV-1 is traditionally associated with orofacial disease, while HSV-2 is traditionally associated with ge***al organs however, lesion location is not necessarily indicative of viral type.
The virus is a double-stranded DNA virus characterized by the following unique biological properties:
a) Neurovirulence (the capacity to invade and replicate in the nervous system)
b) Latency (the establishment and maintenance of latent infection in nerve cell ganglia proximal to the site of infection): In orofacial HSV infections, the trigeminal ganglia are most commonly involved, while, in ge***al HSV infection, the sacral nerve root ganglia (S2-S5) are involved.
c) Reactivation: The reactivation and replication of latent HSV, always in the area supplied by the ganglia in which latency was established, can be induced by various stimuli (eg, fever, trauma, emotional stress, sunlight, menstruation), resulting in overt or covert recurrent infection and shedding of HSV.
In immunocompetent persons who are at an equal risk of acquiring HSV-1 and HSV-2 both orally and ge***ally, HSV-1 reactivates more frequently in the oral rather than the ge***al region.
Similarly, HSV-2 reactivates 8-10 times more commonly in the ge***al region than in the orol***al regions.
Reactivation is more common and severe in immunocompromised individuals.
Dissemination of herpes simplex infection can occur in people with impaired T-cell immunity, such as in organ transplant recipients and in individuals with AIDS.
Herpes simplex virus is transmitted by close personal contact, and infection occurs by inoculation of virus into susceptible mucosal surfaces (eg, oropharynx, cervix, conjunctiva) or through small cracks in the skin.
The virus is readily inactivated at room temperature and by drying; hence, aerosol and fomitic spread are rare.
Herpes simplex virus type-1 infections transmitted via saliva are common in children, although primary herpes gingivostomatitis can be observed at any age.
Herpes simplex virus type-2 infections are clustered perinatally (from a maternal episode at delivery) and primarily once s*xual activity begins.
Herpes simplex virus type-2 ge***al infections in children can be an indication of s*xual abuse.
Increased age (after onset of s*xual activity) and total number of s*xual partners are independent factors associated with increased seroprevalence of HSV-2 antibodies.
SIGNS AND SYMPTOMS
The clinical course of herpes simplex infection depends on
a) the age and immune status of the individual,
b) the anatomic site of involvement, and
c) the antigenic virus type.
Primary herpes simplex virus (HSV)–1 and HSV-2 infections are accompanied by systemic signs, longer duration of symptoms, and higher rate of complications.
Recurrent episodes are milder and shorter. Both HSV-1 and HSV-2 can cause similar ge***al and orofacial primary infections after contact with infectious secretions containing either HSV-1 (usually oral secretions) or HSV-2 (usually ge***al secretions).
It includes:
1) Acute herpetic gingivostomatitis
This is a manifestation of primary HSV-1 infection that occurs in children aged 6 months to 5 years. Adults may also develop acute gingivostomatitis, but it is less severe and is associated more often with a posterior pharyngitis.
Infected saliva from an adult or another child is the mode of infection. The incubation period is 3-6 days.
Clinical features include the following:
a) Abrupt onset
b) High temperature (102-104°F)
c) Anorexia and listlessness
d) Gingivitis (This is the most striking feature, with markedly swollen, erythematous, friable gums.)
e) Vesicular lesions (These develop on the oral mucosa, tongue, and lips and later rupture and coalesce, leaving ulcerated plaques.)
f) Tender regional lymphadenopathy
Perioral skin involvement due to contamination with infected saliva
Course:
Acute herpetic gingivostomatitis lasts 5-7 days, and the symptoms subside in 2 weeks. Viral shedding from the saliva may continue for 3 weeks or more.
2) Acute herpetic pharyngotonsillitis
In adults, oropharyngeal HSV-1 infection causes pharyngitis and tonsillitis more often than gingivostomatitis.
it comes with
a) Fever,
b) malaise,
c) headache, and sore throat
Vesicles formed rupture to form ulcerative lesions with grayish exudates on the tonsils and the posterior pharynx.
Associated oral and l***al lesions occur in fewer than 10% of patients.
HSV-2 infection can cause similar symptoms and can be associated with oroge***al contact or can occur concurrently with ge***al herpes.
Herpes l***alis
This is the most common manifestation of recurrent HSV-1 infection.
A prodrome of pain, burning, and tingling often occurs at the site, followed by the development of erythematous papules that rapidly develop into tiny, thin-walled, intraepidermal vesicles that become pustular and ulcerate.
In most patients, fewer than two recurrences manifest each year, but some individuals experience monthly recurrences.
Maximum viral shedding is in the first 24 hours of the acute illness but may last 5 days.
GE***AL HERPES
The severity and frequency of the disease and the recurrence rate depend on numerous factors,
a) including viral type,
b) prior immunity to autologous or heterologous virus,
c) gender, and
d) immune status of the individual.
Primary ge***al herpes
Primary ge***al herpes can be caused by both type-1&2 Herpes simplex viruses
The clinical features and course of primary ge***al herpes caused by both HSV-1 and HSV-2 are indistinguishable, but recurrences are more common with HSV-2.
Primary ge***al herpes is characterized by severe and prolonged systemic and local symptoms. The symptoms of persons with a first episode of secondary HSV-2 infection are less severe and of shorter duration.
Preexisting antibodies to HSV-1 have an ameliorating effect on disease severity caused by HSV-2.
Prior orol***al HSV-1 infection protects against ge***al HSV-1 but not HSV-2.
Symptoms of primary ge***al herpes are more severe in women, as are complications.
Clinical features:
The incubation of primary ge***al herpes period is 3-7 days (range, 1 d to 3 wk).
Constitutional symptoms include:
a) fever,
b) headache,
c) malaise (general ill-feeling)
d)myalgia or muscle pain (prominent in the first 3-4 d).
Local symptoms include:
a) pain,
b) itching,
c) dysuria (painful micturition),
d) va**nal and urethral discharge, and
e) lymphadenopathy (swollen and painful lymph nodes).
Clinical features in women:
a) Herpetic vesicles appear on the external ge***alia, l***a majora, l***a minora, va**nal vestibule, and introitus.
b) In moist areas, the vesicles rupture, leaving exquisitely tender ulcers.
c) The va**nal mucosa appear inflamed and edematous.
d) The cervix is involved in 70%-90% of cases and is characterized by ulcerative or necrotic cervical mucosa.
e) Cervicitis is the sole manifestation in some patients.
f) Dysuria ( painful micturition) may be very severe and may cause urinary retention. Dysuria is associated with urethritis, and HSV can be isolated in the urine.
HSV-1 infection causes urethritis more often than does HSV-2 infection.
Clinical features in men:
a) Herpetic vesicles appear in the g***s p***s, the prepuce, the shaft of the p***s, and sometimes on the sc***um, thighs, and buttocks.
b) In dry areas, the lesions progress to pustules and then encrust.
c) Herpetic urethritis occurs in 30%-40% of affected men and is characterized by severe dysuria and mucoid discharge.
The peria**l area and re**um may be involved in persons who engage in a**l in*******se, resulting in herpetic proctitis.
In men and women, the ulcerative lesions persist from 4-15 days until encrusting and reepithelialization occur.
New lesions occur during the course of the illness in 75% of patients, usually forming in 4-10 days. The median duration of viral shedding is about 12 days.
Recurrent ge***al herpes
The major morbidity of ge***al herpes is due to its frequent reactivation rate. In one study, 90% of patients reactivated within the first 12 months. In patients with HSV-2 infection, 38% had 6 recurrences in 1 year, and 20% had more than 10 recurrences in the first year.
Both subclinical and symptomatic reactivation is more common in HSV-2 infection than in HSV-1 infection. Sixty percent of patients with primary ge***al HSV-2 infection experience recurrences in the first year.
Patients who had severe primary ge***al herpes tend to have more frequent recurrences of longer duration.
Recurrent ge***al herpes is preceded by a prodrome of tenderness, pain, and burning at the site of eruption that may last from 2 hours to 2 days. In some patients, severe ipsilateral sacral neuralgia occurs.
In women, the vesicles are found on the l***a majora, l***a minora, or perineum. The lesions are often very painful. Fever and constitutional symptoms are uncommon. The lesions heal in 8-10 days, and viral shedding lasts an average 5 days. The symptoms are more severe in women than men.
In men, recurrent ge***al herpes presents as 1 or more patches of grouped vesicles on the shaft of the p***s, prepuce, or g***s. Urethritis is uncommon. Pain is mild, and lesions heal in 7-10 days. The frequency and severity of recurrences decrease with time.
Subclinical ge***al herpes
Most primary ge***al HSV infections are asymptomatic, with 70%-80% of seropositive individuals having no history of known ge***al herpes. However, upon education regarding the varied clinical manifestations, many patients recognize the symptoms of ge***al herpes.
Truly asymptomatic viral shedding may occur in 1%-2% of infected immunocompetent persons and may be as high as 6% in the first few months after acquisition of the infection.
This property is important when attempting to prevent transmission s*xually or perinatally.
PREVENTION
As with almost all s*xually transmitted infections, women are more susceptible to acquiring ge***al HSV-2 than men.
On an annual basis, without the use of antivirals or condoms, the transmission risk of HSV-2 from infected male to female is about 8–11%.
This is believed to be due to the increased exposure of mucosal tissue to potential infection sites.
Transmission risk from infected female to male is around 4–5% annually.
To avoid unprotected s*x to prevent ge***al herpes infection
pregnant women must seek treatment as early as possible to prevent infecting their babies in the process of delivery.
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