Center for Clinical Epidemiology and Outcomes (CLEO) Research was established in 2011 with the joint collaboration of the First and Second University Departments of Pediatrics of the "Aghia Sophia" and "P. & A.
Antibiotic stewardship means using the right drug, at the right dose, for the right duration and only when truly needed.
At CLEO, we empower hospitals to put stewardship into practice. Through national and international collaborations, we provide real-world data on antibiotic consumption, resistance patterns, and patient outcomes, helping clinicians make informed decisions.
Antibiotic stewardship isn’t about using less, it’s about using better. Every responsible prescription today helps preserve the effectiveness of antibiotics for tomorrow.
18/11/2025
November 18 - World AMR Awareness Week begins!
Today marks the start of World Antimicrobial Resistance Awareness Week (Nov 18 - 24). At CLEO, we work alongside hospitals, healthcare professionals, and policymakers to confront AMR through practical, data-driven solutions.
Our initiatives include:
📌 The GRIPP-SNF Program, strengthening infection prevention capacity across Greek hospitals
📌 The PHIG Project, the first nationwide hospital infection surveillance in Greece as well as continuous education programs on antimicrobial stewardship and infection control Antimicrobial resistance affects everyone.
Preventing it requires action from hospitals, professionals, policymakers, and citizens alike.
Join us in raising awareness and commitment for a safer, healthier future! 🌍
17/11/2025
World Prematurity Day - November 17
💜 We owe it to babies, families, and future generations to act now on preterm births.
Every year, 1 in 10 babies around the world is born too soon. Prematurity is the leading cause of preventable child deaths, and more than 80% of these occur in low- and middle-income countries.
Progress in child survival will not be possible without improving outcomes for small and preterm babies. Failing to provide the care they need means losing lives and futures full of love, learning, and opportunity.
At CLEO, we work every day to strengthen neonatal safety and care. Through the GRIPP-SNF (Greek Infection Prevention Program), we have supported infection prevention and surveillance in neonatal wards, helping reduce hospital-acquired infections and protect premature newborns, the most vulnerable patients of all.
Investing in quality care for small and sick newborns means giving every baby a stronger, more hopeful future💜
14/11/2025
November 14 - World Diabetes Day: Infection risk in chronic illness
People living with diabetes are at significantly higher risk for bacterial and fungal infections, often leading to complications and longer hospital stays.
These patients also face a higher likelihood of receiving broad-spectrum antibiotics
contributing to AMR when prevention and targeted treatment are lacking.
CLEO supports evidence-based infection prevention in chronic disease care by:
- Using real-world data to understand infection patterns among diabetic patients
- Supporting hospitals in implementing prevention protocols
- Promoting rational antibiotic use and patient safety initiatives
12/11/2025
Pneumonia is a leading infectious killer of adults as well, with the elderly being particularly vulnerable.
Hospital-acquired pneumonia, especially in intensive care units, is a major contributor to antimicrobial resistance and prolonged hospital stays.
At CLEO, we focus on prevention through evidence-based protocols, infection surveillance, and education for healthcare teams. From neonatal units to adult ICUs, every infection prevented is a life protected.
24/10/2025
October is Breast Cancer Awareness Month!
And early detection saves lives.
At CLEO, we stand with women, families, and healthcare professionals by promoting research-driven, reliable information on prevention, screening, and treatment pathways.
Together, we can empower more women to recognize the importance of screening and access quality care.
21/10/2025
🍂 As the weather gets colder, flu and COVID-19 continue to challenge public health.
💉 Vaccination remains the strongest shield. And the data speak for themselves:
• Vaccines have saved 154 million lives over the past 50 years (WHO)
• Each year, influenza vaccination prevents 3-5 million severe cases worldwide
✅ Science, prevention, and trust in public health save lives, every season.
15/10/2025
Be a Handwashing Hero!
Today, at Global Handwashing Day (15 October), we pay tribute to Ignaz Semmelweis, the “savior of mothers” who first proved that simple handwashing could drastically reduce maternal deaths in maternity wards.
His legacy lives on: proper hand hygiene reduces gastrointestinal infections by 30% and respiratory infections by 20% (WHO).
At CLEO, we continue this mission, advocating for infection prevention practices that protect patients every day!
11/10/2025
European Organ Donation Day | October 11
🫀 Organ donation saves lives and depends on trust, safety, and science.
Today, on European Organ Donation Day, we recognize the importance of building strong, safe, and transparent systems that make transplantation possible.
At CLEO, we focus on the link between infection prevention, clinical outcomes, and patient safety, all crucial in protecting both organ donors and recipients.
Through data, surveillance, and continuous education, we help healthcare teams minimize post-transplant infections and improve survival rates.
Organ donation is an act of generosity. Ensuring that every donation leads to the best possible outcome is our shared responsibility.
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🫀 Η δωρεά οργάνων σώζει ζωές και βασίζεται στην εμπιστοσύνη, την ασφάλεια και την επιστήμη.
Σήμερα, με αφορμή την Ευρωπαϊκή Ημέρα Δωρεάς Οργάνων, αναδεικνύουμε τη σημασία της δημιουργίας ισχυρών, ασφαλών και διαφανών συστημάτων μεταμοσχεύσεων.
Στο CLEO, εστιάζουμε στη σχέση μεταξύ πρόληψης λοιμώξεων, έκβασης νοσηλείας και ασφάλειας των ασθενών, όλες κρίσιμες παράμετροι για την προστασία τόσο των δοτών όσο και των ληπτών οργάνων.
Η δωρεά οργάνων είναι πράξη προσφοράς. Η διασφάλιση της ασφάλειας και της επιτυχίας κάθε μεταμόσχευσης είναι ευθύνη όλων μας.
11/10/2025
World Hospice & Palliative Care Day - 11 October
On World Hospice & Palliative Care Day (11 October), CLEO reminds us that palliative care is not only about pain management. Preventing infections (such as those linked to catheters) is critical to improving quality of life.
Palliative care is not only about pain relief and dignity, it’s also about ensuring patient safety. In hospices and palliative care settings, patients often have weak immune system and are at higher risk of infections.
Preventing infections is a cornerstone of quality care and a strong defense against antimicrobial resistance (AMR), one of the greatest global health threats.
We at CLEO, we stand out for preventing hospital infections, monitoring antibiotic use, and enhancing infection control practices across adult and pediatric settings
10/10/2025
💚 Mental health is a vital part of public health
Mental wellbeing affects how patients recover and how healthcare professionals perform under pressure. Long hospitalizations, infectious diseases, and demanding clinical environments can have a severe impact on mental health.
At CLEO, we recognize that protecting mental health is part of protecting public health. By promoting safe workplaces, responsible workloads, and open dialogue in hospitals, we support both patients and healthcare professionals.
07/10/2025
This past weekend, CLEO had the honor to collaborate with Penta Foundation - Child Health Research-, University of Nicosia, National & Kapodistrian University of Athens and Università degli Studi di Padova for an educational workshop on Infection Prevention and Control in Paediatric Settings.
Healthcare-associated infections (HAIs) remain the most frequent adverse event in healthcare, affecting an estimated 4.3 million patients in the EU/EEA each year, with a prevalence of around 8%. The burden in disability-adjusted life years (DALYs) from six major HAIs is twice that of 32 other infectious diseases combined.
Up to 65 - 70% of central line-associated bloodstream infections (CLABSIs), and likely many other HAIs, can be prevented through evidence-based IPC strategies. Preventing HAIs not only reduces infection burden but also limits the unnecessary use of antibiotics, making IPC essential in tackling both HAIs and antimicrobial resistance (AMR).
The course aimed exactly at strengthening these skills, promoting effective surveillance, prevention strategies, and adherence to evidence-based guidelines to reduce the impact of resistant infections in healthcare settings.
We’re grateful to everyone who contributed to this meaningful exchange of knowledge and practice and last but not least, we would like to share a heartfelt shoutout to Areteion Medicals for their invaluable collaboration and support throughout this initiative.
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CLEO Κέντρο Κλινικής Επιδημιλογίας και Έκβασης Νοσημάτων
Το Κέντρο Κλινικής Επιδημιολογίας και Έκβασης Νοσημάτων (CLEO) ιδρύθηκε το 2011 υπό την αιγίδα της Α’ & Β’ Πανεπιστημιακής Παιδιατρικής Κλινικής της Ιατρικής Σχολής του Πανεπιστημίου Αθηνών, με δωρεά του Ιδρύματος «Σταύρος Νιάρχος». Το όραμα του CLEO ήταν η βελτίωση της ασφάλειας των ασθενών και της ποιότητας των παρεχόμενων υπηρεσιών υγείας στα ελληνικά νοσοκομεία με έμφαση στην πρόληψη των νοσοκομειακών λοιμώξεων και στην ορθολογική χρήση των αντιβιοτικών. Από τον Οκτώβριο του 2014 το CLEO λειτουργεί ως Αστική μη Κερδοσκοπική Εταιρία.
Από τον Ιούλιο του 2012 έως τον Δεκέμβριο του 2015, οι δράσεις του CLEO στόχευαν στην πρόληψη των νοσοκομειακών λοιμώξεων και στην ορθή χρήση των αντιβιοτικών στα δύο Γενικά Νοσοκομεία Παίδων της Αθήνας, «Η Αγία Σοφία» και «Παναγιώτη και Αγλαΐας Κυριακού». Πιο συγκεκριμένα, επικεντρώθηκαν στο σχεδιασμό και την εφαρμογή εκπαιδευτικών παρεμβάσεων για τη διάδοση των κατάλληλων πρακτικών με στόχο τη βελτίωση της ποιότητας των παρεχόμενων υπηρεσιών υγείας και την υιοθέτηση διεθνώς καθιερωμένων κατευθυντήριων οδηγιών στην καθημερινή κλινική πράξη. Η ερευνητική ομάδα του CLEO συνεργάστηκε με εξειδικευμένο διδακτικό, ερευνητικό, ιατρονοσηλευτικό και διοικητικό προσωπικό, από την Ελλάδα και το εξωτερικό, για να σχεδιάσει και να αναπτύξει αυτές τις παρεμβάσεις, να τις εφαρμόσει και να εκτιμήσει την αποτελεσματικότητά τους.
Τα ενθαρρυντικά αποτελέσματα του προγράμματος παρείχαν αισιοδοξία για τη δυνατότητα ελέγχου και πρόληψης των νοσοκομειακών λοιμώξεων και κατ’ επέκταση της έκβασης της υγείας των ασθενών. Η αυξανόμενη πεποίθηση ότι οι νοσοκομειακές λοιμώξεις μπορούν να προληφθούν σε ένα μεγάλο ποσοστό, έχει εγείρει το ενδιαφέρον αρκετών μονάδων υγείας, οι οποίες επιθυμούν να συμμετάσχουν στην επέκταση του προγράμματος. Από τον Ιανουάριο του 2016, το CLEO διευρύνει τα πεδία δράσης του, τόσο στα νοσηλευόμενα παιδιά όσο και στους νοσηλευόμενους ενήλικες σε όλη την Ελλάδα. Στα πεδία δράσης του εντάσσονται:
Η επιτήρηση και η πρόληψη των πιο συχνών νοσοκομειακών λοιμώξεων.
Η επιτήρηση και η βελτίωση της συμμόρφωσης σε επιλεγμένες πρακτικές πρόληψης.
