06/02/2026
Obstructive sleep apnea (OSA) is characterized by repeated airway collapses during sleep and is associated with a lower success rate in in vitro fertilization (IVF) in women with polycystic o***y syndrome (PCOS).
A prospective study at the Beijing Center for Reproductive Medicine included 360 infertile patients with PCOS between 2019 and 2022, who were evaluated using the Home Sleep Apnea Test (HSAT) before initiating fertility treatment.
The prevalence of OSA was 30% in this population, with significantly lower rates of clinical pregnancy and live births after the first embryo transfer cycle compared to those without OSA. Multivariate analysis confirmed that OSA is an independent risk factor for the reduced live birth rate.
This group presented lower levels of anti-Müllerian hormone (AMH) and higher rates of insulin resistance, hyperlipidemia, and metabolic syndrome—endocrine-metabolic alterations that appear to affect ovarian function, endometrial receptivity, and IVF success.
This finding reinforces the importance of diagnosing and treating OSA to improve reproduction.