20/02/2024
Over the past 20 years, a rising prevalence of Crohn’s disease (CD) has been observed in Asian countries including Hong Kong. Apart from anti-TNF agents adalimumab and infliximab, some newer agents such as vedolizumab for anti-α4β7 integrin receptors, and ustekinumab for anti- interleukin (IL)-12 and anti-IL-23 are also available in Hong Kong. This review aims to summarize the four monoclonal antibodies (mABs): adalimumab, infliximab, ustekinumab and vedolizumab, in terms of indications, mechanisms of action, pharmacokinetics, dosing regimen, efficacy and adverse effects. The key clinical features of the mABs in treating CD are also discussed.
Drugs & Therapeutics
Review of Monoclonal Antibodies for the Treatment of Crohn’s Disease
HKPharm J Volume 30 (2), May-Aug-2023 (2023-12-21): P.43-52
Over the past 20 years, a rising prevalence of Crohn’s disease (CD) has been observed in Asian countries including Hong Kong. Apart from anti-TNF agents adalimumab and infliximab, some newer agents such as vedolizumab for anti-α4β7 integrin receptors, and