31/05/2023
許久沒PO新文章
今天來翻譯密西根州立大學的文章
老年發生喉頭癱瘓多發神經病變
(GOLPP)
GOLPP是一種常見於老年的大型犬的喉神經分布退化的臨床疾患
生病的狗表現呼吸嗚喘。運動不耐久。缺氧 常常清喉嚨甚至昏闕。
治療可以包括手術矯正令呼吸較順𣈱，通常也很有效。最常見的手術後併發症是吸入性肺炎。
在密西根州立大學（MSU)的研究報告指出。食道的功能常常也在這些GOLPP的狗同時下降。所以懷疑是相似的神經退化過程同時導致咽喉和食道的功能變差。因為食道功能變差。所以咽喉手術後，併發吸入性肺炎的情況也因此增加。無可避免的，隨時間流逝。有咽喉問題的狗狗。就算手術改善了呼吸。我們還是會面對全身性的神經退化。通常由後腳無力開始。
由於以上的發現。以前稱為自發性喉頭癱瘓的疾病。事實上是一種全身性神經病變的初期症狀。
所以將其更名為老年發生喉頭癱瘓多發神經病變(GOLPP)更為貼切
下面是原文和出處
Geriatric onset laryngeal paralysis polyneuropathy
GOLPP is a common clinical condition affecting geriatric, large-breed dogs in which the laryngeal innervation degenerates over time.
Affected dogs exhibit respiratory stridor, exercise intolerance, dyspnea, throat clearing, and may even collapse. Treatment includes surgical correction to relieve breathing, and is generally very successful. The most common post-operative risk is aspiration pneumonia.
Studies at MSU have shown that esophageal function is also affected in these dogs. It is suspected that a similar neurodegenerative process causes both laryngeal and esophageal changes. As esophageal function deteriorates, risk of post-op aspiration pneumonia increases. Over time, affected dogs will invariably progress to show generalized neurologic deterioration, initially most notable in their hind limbs. Overall, it appears idiopathic laryngeal paralysis is in fact part of a progressive generalized neuropathy. Due to these findings, it was determined the disease might be better termed geriatric onset laryngeal paralysis polyneuropathy, or GOLPP.
