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Indonesian Journal of Obstetrics and Gynecology

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Indonesian Journal of Obstetrics and Gynecology

official Publication of: Indonesian Society of Obstetrics & Gynecology

16/02/2025

Carbetosine, a Long-acting Oxytocin Agonist, as a Uterotonic in the Prevention of the Occurrence of Postpartum Bleeding

Discussion :
Our current meta-analysis compared the effectiveness of carbetocin as a uterotonic drug in reducing the risk of postpartum hemorrhage. Patients administered carbetocin exhibit a significantly lower risk of bleeding compared to those receiving other uterotonic treatments. Previous research involved a comparison between carbetocin and oxytocin to prevent postpartum hemorrhages. This study revealed that carbetocin reduced the necessity for uterotonics particularly those who underwent cesarean deliveries. However, vaginal delivery did not yield the same outcomes. The study found no significant difference between using carbetocin, oxytocin, or another control in terms of reducing the risk of postpartum hemorrhage, which is defined as any blood loss greater than 500 ml, or the threat of severe PPH, which is defined as a condition of blood loss greater than 1000 ml.

13/02/2025

Carbetosine, a Long-acting Oxytocin Agonist, as a Uterotonic in the Prevention of the Occurrence of Postpartum Bleeding

Conclusion :
Carbetocin, with its effectiveness and efficacy, can be considered as one modality for preventing postpartum hemorrhage in comparison to other uterotonic agents, such as misoprostol and oxytocin. In addition to that, it can benefit women at risk of having a major obstetric hemorrhage.

07/02/2025

Carbetosine, a Long-acting Oxytocin Agonist, as a Uterotonic in the Prevention of the Occurrence of Postpartum Bleeding

Results :
This study involved 12 clinical trials involving a total sample of 32,312 people. Based on forest plot analysis, it was found that patients receiving carbetocin therapy had a 0.42 times lower risk of developing postpartum compared to those receiving other uterotonic agents (misoprostol and oxytocin) (OR: 0.42; 95% CI: 0.26-0.68; p

04/02/2025

Carbetosine, a Long-acting Oxytocin Agonist, as a Uterotonic in the Prevention of the Occurrence of Postpartum Bleeding

Introduction :
Maternal deaths are estimated to occur at a rate of 140,000 annually, or 1 woman every 4 minutes, according to World Health Organization (WHO) data. Additionally, postpartum bleeding may cause up to 25% of maternal deaths. Estimated that 100,000 maternal deaths occur annually. Nearly a quarter of all maternal deaths worldwide occur after childbirth, with postpartum hemorrhage being the leading cause in low-income nations like Indonesia.

31/01/2025

Carbetosine, a Long-acting Oxytocin Agonist, as a Uterotonic in the Prevention of the Occurrence of Postpartum Bleeding

Methods :
Medical search engines such as Pubmed, Google Scholar, and Cochrane were used for literature searches. The literature covered the period from 2013 to 2023. Keywords used were “Carbetocin” or “long-acting oxytocin” and “uterotonic”, “post-partum hemorrhage” or “post-partum bleeding.” Data analysis was conducted using the RevMan 5.4 application.

29/01/2025

Selamat Tahun Baru Imlek 2025/2576 Kongzili!

Semoga ditahun ini kita semua selalu dipenuhi kebahagiaan dan keberkahan.

21/01/2025

Serum Vitamin D Levels, Visual Analog Scale Dysmenorrhea Score, and Endometriosis ASRM Classification: a Relationship Study

Conclusion :
In this study, serum vitamin D levels exhibited a significant positive strong correlation with the VAS dysmenorrhea score (r = 0.678; p = 0.000), along with a very strong positive correlation with the degree of ASRM endometriosis (r = 0.774; p = 0.000). To enhance our comprehension of the complex interplay among serum vitamin D levels, dysmenorrhea, and endometriosis, future research should prioritize several key
areas. Primarily, addressing the limitation of the current study's relatively small sample size is crucial. Conducting research with a larger and more diverse participant pool would enhance the generalizability and robustness of the findings. Longitudinal studies tracking changes in these variables over time would elucidate causality and the dynamic nature of these relationships. Furthermore, investigating additional potential confounding variables, such as dietary practices, lifestyle factors, and other health-related aspects, could offer nuanced insights into these associations. Moreover, employing random sampling strategies instead of patient selection based on the day of diagnosis would mitigate bias in participant selection, resulting in a more representative cohort of women affected by endometriosis. This adjustment would ultimately yield more precise and valuable outcomes for future research endeavors.

16/01/2025

Serum Vitamin D Levels, Visual Analog Scale Dysmenorrhea Score, and Endometriosis ASRM Classification: a Relationship Study

Discussion :
In this study, 37 women were involved, and the mean age of endometriosis patients was 34.41 ± 6.86 years (range 22 – 48 years). This is in line with the study which found that the average age of endometriosis patients was 34.22 ± 6.54 years (range 18 – 45 years). These results were not much different from where the average age of the patients was obtained. endometriosis in the two treatment groups in their study amounted to 33.4 ± 0.892 years and 34.7 ± 0.925 years. Similarly, a study reported an average age of endometriosis patients of 33.3 ± 6.23 years. In this study, most endometriosis patients had a normoweight body mass index (59.5%) with an average BMI of endometriosis patients in this study of 24.12 ± 3.34 kg/m2 (range 18.2 – 31.2 kg/m2). Another study found similar results which reported endometriosis patients BMI was reported to be 23.48 ± 1.90481. The average BMI of endometriosis patients ranged from 22.46 to 23 kg/m2. A greater average BMI of 27.1 ± 0.752 kg/m2 and 27.8 ± 0.710 kg/m2. Research found a lower mean BMI of 21.1 (15.2–33.5 kg/m2) and reported no difference in mean BMI between endometriosis patients and healthy controls (p > 0.05).

10/01/2025

Serum Vitamin D Levels, Visual Analog Scale Dysmenorrhea Score, and Endometriosis ASRM Classification: a Relationship Study

Results :
There was a significant positive correlation between vitamin D levels and the VAS score for dysmenorrhea (r = 0.678; p = 0.000) and a very strong positive correlation between vitamin D levels and the degree of endometriosis (r = 0.774; p = 0.000) based on Spearman Rho's correlation test.

06/01/2025

Serum Vitamin D Levels, Visual Analog Scale Dysmenorrhea Score, and Endometriosis ASRM Classification: a Relationship Study

Methods :
A cross-sectional study was conducted involving 37 women diagnosed with suspected endometriosis who met the inclusion and exclusion criteria. The aim was to determine the correlation between vitamin D levels, dysmenorrhea VAS scores, and the ASRM endometriosis stage at RSUP Dr. Mohammad Hoesin Palembang from November 2021 to April 2022. Bivariate analysis was employed to assess correlation, utilizing Pearson's correlation test and the Spearman Rank correlation test as an alternative method.

01/01/2025

Happy New Year 2025! May this new year all your dreams turn into reality.

25/12/2024

Merry Christmas and Happy New Year!

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Tuesday	08:00 - 16:00
Wednesday	08:00 - 16:00
Thursday	08:00 - 16:00
Friday	08:00 - 16:00

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