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Seattle University’s Groundbreaking Portable Artificial Kidney Could Transform DialysisPatients suffering from kidney fa...
17/09/2024

Seattle University’s Groundbreaking Portable Artificial Kidney Could Transform Dialysis
Patients suffering from kidney failure often have to spend hours each week hooked up to dialysis machines to survive. However, a new invention being developed at Seattle University aims to change that. With over 600,000 people in the U.S. requiring dialysis, this innovative project could significantly improve their quality of life.
Dr. Shen Ren, an assistant professor of mechanical engineering at Seattle University, specializes in heat transfer, thermodynamics, and fluid mechanics. While these areas are his expertise, his current research focuses on something entirely different—one of the body’s most vital organs, the kidney.
"This is an artificial kidney," says Dr. Ren. While it may not resemble a kidney, his vision is for it to function just like one. "Imagine a portable artificial kidney, a dialysis system you can take with you. That means patients could perform dialysis anywhere they go."
Dr. Ren is collaborating with the University of Washington’s Center for Dialysis Innovation (CDI) and the Northwest Kidney Centers to bring this vision to life. The team is working to develop a device about the size of a backpack. Since 2017, Dr. Ren has worked with CDI to redesign the traditional dialysis machine—typically confined to a clinic—into a portable version that patients can carry with them, offering a new level of freedom and a vastly improved quality of life.
"This could change the lives of millions of people around the world," Dr. Ren emphasized.
One of those people is Becca Chong, who was diagnosed with Alport syndrome in her twenties, leading to kidney failure. "It was incredibly burdensome," Chong recalls. "I was 25, with my whole life ahead of me. While my friends were out enjoying life, I had to structure my entire day around a dialysis machine."

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In a groundbreaking medical first, a kidney from a genetically modified pig has been successfully transplanted into a hu...
17/09/2024

In a groundbreaking medical first, a kidney from a genetically modified pig has been successfully transplanted into a human. William Brangham reports that this recent procedure marks a significant step forward in medicine and could have far-reaching implications.
The patient, a 62-year-old Black man, had been on dialysis for years due to kidney failure. This type of transplant, known as xenotransplantation, uses animal organs for human patients and is seen as a potential solution to the severe shortage of human organs. Thousands of people are waiting for organ transplants, but the lack of available organs means many die before receiving one. However, using animal organs in humans comes with challenges—primarily the body’s tendency to reject foreign tissue. In this case, scientists were able to remove several genes from the pig that would normally cause the body to reject the organ.
To help explain this new medical frontier, Dr. Leonardo Riella, the medical director for kidney transplants at Massachusetts General Hospital, joined the discussion. His hospital was where this historic procedure took place.
Progress and Prognosis
Dr. Riella confirmed that the patient is doing extremely well following the surgery. While most kidney transplant patients stay in the hospital for five to six days, they plan to monitor this patient for about a week to nine days. Since receiving the pig kidney, the patient has been off dialysis, which is a positive sign of the transplant’s success.
Emotional Milestone
At the press conference announcing the breakthrough, Dr. Riella was visibly moved. When asked what his younger self in medical school would think of curing end-stage kidney disease with a pig’s kidney, he responded that it was once a dream that he thought might never come true.
Overcoming Major Challenges
Animal-to-human transplants have been attempted before, but previous efforts faced significant obstacles, mainly due to incompatibilities between animal and human DNA.

09/09/2024

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