25/03/2026
Tirzepatide and swelling
90% of Lipedema patients report a significant improvement in swelling and pain during the day while on Tirzapatide. Then...they come off it pre surgery and their legs start to swell up again and the pain comes back ....let me explain...
👉 Tirzepatide alone isn't going to fix the fundamental issue causing Lipedema swelling and pain⏩fibrosis. Tirzepatide is a messenger and it helps to calm down things while you get to work on improving the system. It reduces the inflammatory chemicals involved in Lipedema but doesn't fix the root cause of why this is happening. So the minute you stop it swelling will come back. That is pretty normal.
👉Digestion has a fundamental part to play in terms of blood vessels health as that's how nutrients are absorbed and carried around the body!! The liver and gallbladder are 2 fundamental organs to keep in top shape. When you take a higher dosage of tirzepatide you are bringing these 2 organs into quite significant stress and potentially increasing inflammation in other areas of the body.
This is WHY keeping the dose low with minimal side effects will make Tirzepatide anti inflammatory effect even more beneficial. You need to address your metabolic health before anything significant will ever change even with Tirzepatide. This is crucial.
A particular thanks to the research work of .ssa_serena_michelini and Sandro Michelini alongside which will continue to shape future better care for Lipedema patients.
Did you know this?