15/03/2026
The one nutrient i see chronically low in 90% of my Lipedema and hEDS clients in clinic....
👉Folate
I barely see adequate serum Folate levels among my Lipedema clients. It is a consistent deficiency I have seen in the clinic for many years.
Before we go to the WHY let me explain how Folate is crucially linked with Adipose tissue disorders.
1️⃣Folate( B9) is a key regulator of Lipid metabolism and Adipogenesis( formation of new fat cells). And deficiencies can increase Leptin levels and increase both Leptin and Insulin resistance promoting chronic inflammation.
In Lipedema I have seen this chronic deficiency been caused by 👇
👉Genetic mutation in the MTHFR gene.These mutations impair the conversion of Folate and Folic acid into its active form of methyltetrahydrofolate( 5-MTHFR). The women with these variants should NOT use the synthetic form of Folic "acid" as the body is simply not able to use this form efficiently and levels can accumulate in the body. High levels of unbound folic acid can lead to immune dysfunctions and inflammatory processes.
👉Coeliac disease, folate receptor antibodies, use of the contraceptive pill, long term use of stomach acid blockers( PPI), certain antibiotic treatments, H. Pylori infections and low stomach acid issues, chronic stress, bariatric surgery, chronic inflammatory disorders like endometriosis and adenomyosis.
🟠In clinic I assess deficiency first taking into consideration that serum levels are not "tissue" levels so they still need to be taken with a pinch of salt. I often check genetics first in most of my clients which can direct to the correct type of supplementation and absorption issues.
There are different types of supplementation that suits some and not others:
❌Folic acid. Should be avoided at all cost
👍Methylfolate. Good form of active folate but not suitable for individuals with anxiety and migraines as it acts as a neuro stimulant.
🔝FoliNIC acid. The best form which increases folate levels very fast and can cross the blood brain barrier. The ideal form for women with ADHD and autism as it supports brain function directly.