23/08/2025
Unexplained infertility is when a couple has difficulty conceiving even after thorough medical evaluations show no identifiable cause.
Key Points:
• Definition: Infertility lasting more than 12 months (or 6 months in women over 35) despite regular, unprotected in*******se, where common tests (ovulation, semen analysis, fallopian tube tests, hormone levels) are all normal.
• Prevalence: About 10–20% of infertile couples are diagnosed with unexplained infertility.
• Possible hidden causes:
• Subtle problems with egg or s***m quality
• Fertilization or implantation issues
• Genetic or immunological factors not detected in routine tests
• Egg-s***m interaction problems
Treatment options:
1. Lifestyle changes – healthy weight, no smoking/alcohol, stress reduction
2. Ovulation induction – medicines like clomiphene or letrozole
3. Intrauterine Insemination (IUI) – placing s***m directly into the uterus
4. In Vitro Fertilization (IVF) – bypasses many hidden causes and offers higher success rates
5. Advanced techniques – like ICSI (Intracytoplasmic s***m injection) or genetic testing in some cases
👉 While the diagnosis can feel frustrating because there’s “no clear reason,” the good news is that many couples with unexplained infertility go on to conceive — either naturally or with fertility treatments.