29/04/2026
🫁 Giant & Pulmonary Complications — What does the evidence show?
A highlights the significant burden of in newborns with giant omphalocele (GO):
🔍 23 studies analyzed (PRISMA-based review)
📊 Key findings (median values):
• Pulmonary hypoplasia : 26%
• Persistent pulmonary hypertension: 38.5%
• Mortality: 23.5%
• Associated syndromes/anomalies: 58%
⚠️ In case series, outcomes were even more severe — with mortality reaching 55.5%.
💡 Key insight:
The combination of associated anomalies and significantly increases mortality risk.
🚨 Take-home message:
Despite heterogeneity across studies, the burden of pulmonary complications in GO is alarmingly high.
➡️ There is an urgent need for:
• Standardized diagnostic criteria
• Improved prenatal counseling
• Management in specialized centers
Read the whole article here: https://www.thieme-connect.com/products/ejournals/abstract/10.1055/a-2649-0781