Dr Gaurang Ramesh

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Dr Gaurang Ramesh

Functional Medicine Practitioner | Surgical Gastroenterologist | Integrative Medicine It treats the whole system, not just the symptoms.

Hi, I'm a Surgeon by profession, Functional Medicine practitioner by passion and an adventurer by heart. I'm currently a resident surgeon in Surgical Gastroenterology at Bangalore Medical College. Functional Medicine seeks to identify and address the root causes of disease, and views the body as one integrated system, not a collection of independent organs divided up by medical specialties. I help

people heal their chronic diseases naturally along with practising surgery. If you want to talk more about functional medicine, integrated gastroenterology or healing chronic disease naturally, hit me up at guthealthdoctor@gmail.com

16/11/2023

🌟 Revolutionizing Mental Health Through Personalized Nutrition: Key Findings from a New Study

📚 Study Details: "A personalized diet intervention improves depression symptoms and changes microbiota and metabolite profiles among community-dwelling older adults."
🔬 Published in: Frontiers in Nutrition, 2023
👩‍🔬 Researchers: Faiga Magzal, Silvia Turroni, Marco Fabbrini, and team

🍏 What's the Big Deal?

Personalized diets have the potential to revolutionize mental health care by reducing depression symptoms and enhancing the quality of life in older adults.
The study also uncovers the intricate relationship between diet, gut microbiota, and mental health.

‍⚕️ My Clinical Insights: In my practice, I've seen remarkable improvements in mental health through personalized dietary interventions. In some instances, we've even been able to taper off or completely stop anti-depression medications, thanks to a focus on gut microbiome and mitochondrial health.

👇 What Do You Think?
Do you believe in the power of diet to transform mental health? Share your thoughts below!

🔗

15/11/2023

🌟 The Maternal Microbiome: A Game-Changer in Placental Health

📚 Study Details: "The maternal microbiome promotes placental development in mice."
🔬 Published in: Science Advances, 2023
👩‍🔬 Researchers: Geoffrey N Pronovost, Kristie B Yu, Elena J L Coley-O'Rourke, and team

🍼 What's the Big Deal?

The maternal gut microbiome is not just important for the mother but also crucial for the healthy development of the placenta.
The study reveals the potential of short-chain fatty acids (SCFAs) in promoting placental health.
👨‍⚕️ My Clinical Insights: In my practice, I've seen the positive impact of a balanced maternal microbiome on pregnancy outcomes. It's an area that deserves more attention in prenatal care.

👇 What Do You Think?
Do you think the maternal microbiome could be the next frontier in prenatal health? Share your thoughts below!

🔗

13/11/2023

🌟 The Gut Mycobiome: Unveiling its Role in Ulcerative Colitis

📚 Study Details: "Dynamics of the Gut Mycobiome in Patients with Ulcerative Colitis."
🔬 Published in: Clinical Gastroenterology and Hepatology, 2023
👩‍🔬 Researchers: Sushrut Jangi, Katie Hsia, Naisi Zhao, and team

🍄 What's the Big Deal?

The study reveals that the abundance of Candida is notably higher during active phases of Ulcerative Colitis.
This opens up new avenues for targeted therapies in UC.
👨‍⚕️ My Clinical Insights: In my practice, I've found that a comprehensive approach to gut health, including addressing fungal imbalances, can make a world of difference in managing UC symptoms.

👇 What Do You Think?
Could targeting the gut mycobiome be the next big thing in treating UC? Share your thoughts below!

🔗

11/11/2023

Magnesium Deficiency in Agriculture: A Critical Concern with Implications for Human Health

A recent review published in the International Journal of Molecular Science sheds light on the often-overlooked issue of Magnesium (Mg2+) deficiency in agriculture. Magnesium is an essential macronutrient that plays a pivotal role in plant growth and development. Yet, it is largely neglected in fertilization management strategies, leading to severe reductions in crop yield and quality.

🌿 Role of Magnesium in Plants

Supports several physiological processes
Vital for morphological, physiological, biochemical, and molecular functions
Regulates Mg2+ homeostasis through specialized transporters
🌍 Impact on Sustainable Agriculture

👨‍⚕️ Magnesium in Human Health
In my practice, I regularly recommend magnesium supplements to patients, especially those dealing with chronic diseases. Magnesium is not just crucial for plant health; it's equally important for human well-being.

🔬 Health Benefits of Magnesium

Supports bone health
Regulates blood pressure
Improves mood and overall mental well-being
Essential for muscle function
Helps in the management of diabetes and cardiovascular diseases

To ensure both sustainable agriculture and improved human health, it's imperative to integrate Magnesium into fertilization management strategies and focus on agronomic and genetic biofortification for creating Mg2+-deficiency-resilient crops.

By addressing the issue of Magnesium deficiency in agriculture, we can not only improve crop yield but also contribute to better human health. It's time to give Magnesium the attention it deserves in both the agricultural and healthcare sectors.

Feel free to share your thoughts and experiences regarding Magnesium's role in agriculture and human health.

02/11/2023

I've received criticism multiple times when I talk about the effects of Xenobiotic Metals on Cardiovascular and Metabolic diseases, especially using chelation therapy in diabetics with evidence of Xenobiotic Metal toxicity.

I was happy to find this trial titled, Chelation Therapy and Cardiovascular Disease: Connecting Scientific Silos to Benefit Cardiac Patients, published in the journal Trends in Cardiovascular Medicine in 2014.

Key Findings:

1. Reduced Cardiovascular Events: A regimen of 40 infusions of disodium EDTA-based chelation therapy was found to safely reduce cardiovascular events in a post-MI population.
2. Role of Xenobiotic Metals: The study suggests that xenobiotic metal pollutants are cardiovascular risk factors.
3. Enhanced Effects with Supplements: The effect of the chelation infusions was found to be enhanced when administered with high doses of oral multivitamins and multiminerals (MVM).
4. Significant Benefit in Diabetic Patients: The therapeutic benefit of the chelation treatment was particularly striking in patients with diabetes.
5. Modern Post-MI Therapy: These results were observed against the backdrop of modern, evidence-based post-MI therapy, implying that chelation could be an additional therapeutic option.

Future Research:
Replication and Mechanism Understanding: Given the unique nature of these findings, the conclusion calls for follow-up research to replicate the results and understand the underlying mechanisms.
Testing Hypotheses: The xenobiotic metal hypothesis and the development of AGEs (Advanced Glycation End-products) and RAGE (Receptor for Advanced Glycation End-products) activation should be tested.
Funding Challenges: There is no pharmaceutical company interest in this generic intervention, and its important for individual doctors who believe in environmental medicine to document their findings and publish them independently.

I believe we should immediately replicate and implement the findings due to the magnitude of the observed benefits. It also notes that given the excellent safety record of chelation therapy, replication and implementation could occur simultaneously.

01/11/2023

Exploring the Therapeutic Potential of Probiotics and Prebiotics in Celiac Disease Management

Celiac Disease (CD) is a complex, immune-mediated enteropathy triggered by gluten exposure in genetically predisposed individuals. While a Gluten-Free Diet (GFD) remains the cornerstone of treatment, it comes with its own set of challenges, including quality of life issues and nutritional deficiencies. A recent study published in Life on October 12, 2023, offers a fresh perspective on the role of gut microbiota in CD and the potential for probiotic and prebiotic intervention.

🦠 The Gut Microbiota-CD Connection
The study delves into the intricate relationship between gut microbiota and CD. It highlights how environmental factors like gut microbiome composition, gestational age, and previous infections can influence the onset of CD. The gut microbiota plays a pivotal role in gluten metabolism, immune response modulation, and maintaining gut permeability.

🌱 Probiotics & Prebiotics: A New Frontier
Recent findings suggest that probiotics, particularly strains like Bifidobacterium and Lactobacillus, could serve as adjuvant therapy for CD patients. These probiotics are involved in gluten metabolism and can potentially reduce adverse reactions associated with a strict GFD. Prebiotics, on the other hand, can stimulate the growth of these beneficial bacteria, thereby regulating gut microbiota and potentially alleviating CD symptoms.

📊 Current Research Gaps
Despite promising in vitro and animal studies, there is a lack of comprehensive human trials to substantiate the effectiveness of probiotics and prebiotics in CD management. The study calls for larger randomized controlled trials to establish the type, dose, and duration of probiotic and prebiotic administration.

👩‍⚕️ Clinical Implications
In my practice, where I often encounter patients with chronic gut health issues, the modulation of gut microbiota through probiotics and prebiotics presents an exciting avenue for adjunctive therapy. This could be particularly beneficial for CD patients who experience persistent symptoms despite adhering to a GFD.

🔍 The Way Forward
The study sets the stage for future research to explore the therapeutic potential of gut microbiota modulation in CD. It also underscores the need for personalized treatment plans that consider genetic risk profiles and disease progression.

🔬 🌱 🦠 🍞 📚

Feel free to share your thoughts and let's keep the conversation going!

30/10/2023

Unlocking the Synergistic Power of Quercetin and Cyclophosphamide in Triple-Negative Breast Cancer (TNBC) Treatment

In the realm of cancer research, the quest for more effective and less toxic treatments is never-ending. There is significant criticism from the medical oncology community in using phytonutrients as complementary therapy because its mechanism of action is unclear and that it may also complement the tumour growth.

In our practice at Arka Anugraha Hospital, we are constantly looking for ways to minimise the side effects of chemotherapeutic drugs and support patient's healing journey.

A recent study published in Pharmaceuticals on October 7, 2023, sheds light on a promising avenue for TNBC patients, a breast cancer subtype notorious for its aggressive nature and limited treatment options.

🌿 The Power of Phytochemicals: Quercetin
The study employed a 4T1 mouse model of TNBC to investigate the effects of quercetin, a phytochemical found in fruits and vegetables. Quercetin not only enhanced the antitumor action of Cyclophosphamide, a commonly used cytotoxic drug in TNBC treatment, but also favorably modified the host's f***l microbiome. Specifically, it enriched species like Akkermansia muciniphilia, known to improve responses to anti-PD-1 therapy.

🔗 Complementary Mechanisms
Interestingly, while Cyclophosphamide did not significantly alter the host microbiome, it did increase the systemic frequency of T cells and NK cells, thereby boosting the antitumor immune response. This suggests that the two agents work through different but complementary mechanisms to potentiate antitumor action.

🌐 Implications for TNBC Treatment
The findings are particularly relevant given that TNBC lacks targeted therapy options like hormone treatment or anti-HER-2neu therapy. The study opens the door for microbiota-centered dietary interventions to overcome resistance to chemoimmunotherapy in TNBC.

👩‍⚕️ From My Practice
In my clinical practice, I often recommend phytochemicals like quercetin for their wide-ranging health benefits, including their role in chronic disease management.

🔍 The Way Forward
The study sets the stage for future research to delve deeper into the causal relationship between microbiome changes and immune responses, potentially leading to more effective and less toxic treatment combinations for TNBC patients.

🔬 🌿 🎗️ 🧬 🦠 🌐

Feel free to share your thoughts and let's keep the conversation going!

28/10/2023

👶 The Power of Colostrum: A Gift from Mother to Newborn

Hey everyone! A fascinating study in Nutrients has highlighted the importance of colostrum in boosting the neonatal immune system. This first milk is not just food; it's a lifeline for newborns.

🤱 Why Colostrum Matters
Colostrum is rich in proteins and bioactive compounds that are crucial for a newborn's immune system. It's especially vital for preterm babies who have an underdeveloped immune system.

👨‍⚕️ From My Practice
In my practice, I've seen the long-term benefits of optimizing the gut microbiome from an early age, and colostrum plays a significant role in this.

🍼 Breast is Best
Breastfeeding should be strongly encouraged. It provides essential immunomodulatory compounds that help newborns face infections and establish tolerance.

❓ What Do You Think?
I'd love to hear your thoughts on the importance of breastfeeding and colostrum in shaping a newborn's immune system and gut microbiome. Share your insights below!

🏷️

26/10/2023

🌿 The Gut Microbiome: A New Horizon in Hepatocellular Carcinoma (HCC) Research

Did you know that the bacteria in your gut could be a game-changer in the fight against liver cancer? A recent review by researchers Betul Gok Yavuz, Saumil Datar, and team explores how the gut microbiome could serve as a biomarker and even a therapeutic target in Hepatocellular Carcinoma (HCC).

🌟 Highlights:

The gut microbiome influences liver diseases, including HCC.
It could serve as an early diagnostic and predictive tool for HCC treatment.
The microbiome may also play a role in the effectiveness of cancer immunotherapies.

🤔 From My Practice:
In my clinical work, I've seen significant improvements in the general condition of patients with fatty liver, liver cirrhosis, and hepatocellular carcinoma through gut microbiome optimization.

What do you think about the role of the gut microbiome in cancer treatment? Share your thoughts below! 👇

25/10/2023

🌿 Bisphenols: The Unseen Environmental and Health Hazard

Did you know that bisphenols, commonly found in plastics and other materials, are not just harmful to humans but also to our environment? A recent study by Magdalena Zaborowska and team dives deep into the toxicity of bisphenols like BPA, BPF, and BPS.

🌟 Key Takeaways:

Bisphenols are toxic to humans and animals, affecting hormonal systems and even leading to cancer.
They also have a negative impact on soil health, affecting microbiomes and plant growth.
🚨 Why It Matters:

Regulatory bodies have started to limit the use of BPA, but its analogs, BPF and BPS, are also concerning.
The study calls for more research on the impact of bisphenols on soil health, crucial for agriculture and ecosystem balance.
🤔 From My Practice:
In treating chronic diseases, I've observed the importance of detoxification from endocrine disruptors like bisphenols, particularly in hormonal diseases such as PCOS.

What are your thoughts on the impact of bisphenols? Leave a comment below if you want a free copy of the PDF of my recommendations to reduce endocrine disruptor exposure. 👇

23/10/2023

🔬 New Research Insight: A Metabolite Perspective on the Involvement of the Gut Microbiota in Type 2 Diabetes

👨‍🔬 Authors: Yifeng Fu, Siying Li, Yunhua Xiao, Gang Liu, Jun Fang
📖 Journal: International Journal of Molecular Sciences, 2023

📌 Key Takeaways:
1️⃣ Dysbiosis in gut microbiota significantly contributes to the onset of Type 2 Diabetes (T2D).
2️⃣ Beneficial metabolites like Short-chain fatty acids (SCFAs) and bile acids (BAs) can improve glucose metabolism.
3️⃣ Elevated levels of harmful metabolites such as lipopolysaccharides (LPS), branched-chain amino acids (BCAAs), and trimethylamine N-oxide (TMAO) are associated with insulin resistance and T2D.
4️⃣ Dietary changes and medications that target the gut microbiome can serve as effective preventive and management strategies for T2D.

📊 From My Practice:
In my practice, I've encountered patients who maintained an impeccable diet and lifestyle yet struggled to reverse their Diabetes. Remarkably, once their gut health issues were addressed, they experienced a reduction in insulin resistance, and it became possible to taper their oral hypoglycemic medications.

👇👇👇
What are your thoughts on the intricate role of gut microbiota metabolites in the management of Type 2 Diabetes? Feel free to share your insights below!

21/10/2023

🔬 New Research Insight: The Multifaceted Role of the Human Microbiome in Health and Disease

📖 Journal: International Journal of Molecular science - Special Issue on Gut Microbial Metabolites

📌 Key Takeaways:
1️⃣ The human microbiome is intricately linked to a myriad of diseases, including cancer, inflammation, and neurodegenerative conditions.
2️⃣ Gut microbiota metabolism has been shown to be closely related to cerebral stroke and Clostridioides difficile infections.
3️⃣ The microbiome plays a significant role in cancer treatment, potentially affecting the effectiveness of chemotherapy and immunotherapy.
4️⃣ Metabolomic technologies are crucial for understanding the role of the gut microbiome in liver cancer and hepatocellular carcinoma.
5️⃣ The microbiome may also be an essential component in the pathogenesis of multiple types of pain, including migraines and gastrointestinal syndromes.

📊 From My Practice:
In my clinical experience, I've observed that maintaining a balanced microbial ecosystem is not just beneficial but essential for overall health. Whether it's resolving chronic gut issues to improve insulin resistance in diabetic patients or optimizing the microbiome to enhance the effectiveness of cancer therapies, the microbiome plays a pivotal role in both disease prevention and treatment.

👇👇👇
What are your thoughts on the expansive role of the human microbiome in various diseases and its potential as a therapeutic target? Share your insights below!
Leave a comment if you want the link for the full article.

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