Mazumdar Shaw Medical Foundation

07/11/2024

Foundation of Head and neck Oncology (FHNO) 2024, 18th - 20th October 2024, in Mumbai.

List of abstracts presented:
1. Artificial Intelligence Integrated Molecular Cytology for Objective Triaging of Thyroid Nodules - Presenter Greeshma
Received Best Podium Presentation Award for Basic Science Research category

2. Clinical validation of inhouse salivary ELISA-based assay with S100A7 and S100P for early detection of oral potential malignant lesions (OPML); Presenter- Ankita P

3. Enhancing Pathologist Consistency: Evaluating Inter-Observer Concordance to Develop Automated Diagnostic Tools for Oral Epithelial Dysplasia- Presenter Anela Thomas
Received Best Poster-podium Presentation Award

4. 'Tumor-lymph node stromal cell cross talk in OSCC: insights into the tumor and stromal cues in nodal metastasis- Presenter Bonney Lee James

5. Transcriptomic profiling of oral potentially malignant disorders: Presenter Gangothri S

6. Label Free Cytology for Early detection of oral cancer in Low Resource Setting- Presenter Sumsum P S
Received Narendra Desai Award for Best Podium presentation for Basic Science Research category

08/01/2024

💥💥Mazumdar Shaw Medical Foundation News & Updates 💥💥

Circular

Nurse Recruitment for Sample Collection from Patients with Neurological Disorders

Invitation Note : Applications are invited from passionate candidates for one post of Research Nurse. We look forward to applications from skillful candidates.

Workplace : Neuroscience Research Lab,
Mazumdar Shaw Medical Foundation (MSMF)
Bangalore-560099, India
Webpage: https://www.msctr.org/integrated-research-on-neuroscience/

Funding Partner : SKAN Research Trust

Working Team : Neuroscience Research Group

Job Title : Research Nurse

Job Type : Contractual

Emoluments : Competitive

Duration : The initial appointment will be for six months, extendable based on the performance in the first six months.

Eligibility : Essential: Diploma in Neuro Nursing (DNN) or Diploma/BSC in Nursing or equivalent diplomas/ degrees. Age, Nationality no bar. Candidates yet to receive their final certificate can apply too.
Desirable:
1. Available to work in MSMF onsite regularly
2. Computer-literate

Experience needed : Candidates with experience in sample collection and biorepository maintenance will be preferred.

Mode of Application : Drop an email Dr. Debprasad Dutta at debprasad@ms-mf.org with the following documents with subject-line “Research Nurse Application at MSMF”:
1. CV (.docx or .pdf or .pptx presentation)
Selected candidates will be informed through emails about subsequent steps to be followed.

Selection Procedure : Shortlisting based on CVs➡️ Online or offline (for Bangalore-based candidates) interviews of shortlisted candidates ➡️ Final selection for joining (top candidate).

Responsibilities : List of duties candidate expected to deliver:
• Collection of biosamples (such as blood, CSF, nasal/buccal swabs, urine, f***l and tissue samples) from patients with neurological disorders.
• Barcoding, labeling and storing Biosamples in an orderly and easily retrievable manner
• Documentation and record-keeping of the collected samples.
• Assisting seniors in developing protocols related to sample collection/storing/recording.
• Participate in team meetings and take action to attain collective project goals.

Integrated Research on Neuroscience Under the umbrella of Mazumdar Shaw Medical Foundation (MSMF) and Narayana Institute of Neurosciences (NIN), MSMC, Narayana Health, The Integrated Research on Neuroscience program has been initiated. One of the main areas of interest is stroke. Stroke is emerging....

19/12/2023

💡💡 Mazumdar Shaw Medical Foundation News and Events 💡💡

Winners of best presentation in MSCTR Journal Club - 2023

Mazumdar Shaw Medical Foundation | MSMF TBI | Mazumdar Shawmf |

10/11/2023

📢 📢 Mazumdar Shaw Medical Foundation News & Updates 📢 📢

1. Anti-CXCR4 inhibitor in reversing resistance to chemoprevention and chemotherapy (Patent No.: 449011)
Patentee: Mazumdar Shaw Medical Foundation, Bangalore
Name of Inventor(s): Dr Moni Abraham Kuriakose, Dr. Amritha Suresh, Ms. Gangotri Siddappa, Dr. Safeena Kulsum
This is a method patent for reversing resistance to chemopreventive and chemotherapeutic drugs. It is an in vitro study, wherein the drug resistance is shown to increase on interaction of epithelial cells with fibroblast cells. Subsequent inhibition of this stromal interaction by blocking the activity of SDF1/CXCR4 pathway using anti-CXCR4 has indicated sensitization of epithelial cells to drugs and hence, killing the dysplastic/cancer cells. Further, development of in-house anti-CXCR4 molecules is being carried out currently.

2. A pharmaceutical formulation comprising curcumin and metformin for head and neck cancer (Patent No.: 462241)
Patentee: Mazumdar Shaw Medical Foundation, Bangalore
Name of Inventor(s): Dr Moni Abraham Kuriakose, Dr. Amritha Suresh, Ms. Gangotri Siddappa, Dr. Safeena Kulsum
This is a pharmaceutical formulation patent that comprises of use of both curcumin and metformin drugs together for chemoprevention of head and neck cancer. The efficacy of both the drugs individually are shown in various cancers including that of head and neck cancer. Here, in our study we have shown that the combination is more efficient as compared to their individual efficacy. A Phase IIb/III trial (Study title: Phase IIb/III study to determine the efficacy of Curcumin and Metformin to reduce the incidence of second primary tumors in aero-digestive tract in patients with history of head and neck squamous cell carcinoma) is also ongoing at Mazumdar Shaw Medical Centre, Narayana Health City, Bangalore for the same drug combination.

Mazumdar Shawmf

10/11/2023

📢 📢 Mazumdar Shaw Medical Foundation News & Updates 📢 📢

CD44-SNA1 integrated cytopathology for delineation of high grade dysplastic and neoplastic oral lesions September 2023 PLoS ONE DOI: 10.1371/journal.pone.0291972

Low patient compliance for biopsies of oral lesions underscores the need for less invasive diagnosis. The primary objective of this study was to ascertain the significance of biomarkers to improve cytology. Towards this effect, a comprehensive systematic review and meta-analysis identified a panel of markers (n: 10) delineating dysplastic oral lesions. Subsequent patient-based validation in tissues (n: 131) identified a four-marker panel, CD44, Cyclin D1, SNA-1, and MAA, with the best sensitivity (>75%; AUC>0.75), while validation by cytology in an independent cohort (n: 133) showed that SNA-1 and CD44 significantly delineate moderate-severe dysplasia (High-grade lesions: HGD) and cancer with high sensitivity (>83%). Multiplex validation in another cohort (n: 138), integrated with a machine learning model incorporating clinical parameters, further improved the sensitivity and specificity (>88%). Image automation using a single marker dataset (SNA-1), wherein a model was developed from morphological and expression features also gave a high sensitivity (86%). Our study indicated that the use of a two-biomarker panel (CD44/SNA-1) integrated with clinical parameters, when multiplexed or integrated with automated image analysis provided efficient risk stratification of oral lesions, indicating the significance of biomarker-integrated cytopathology in the development of a Point-of-care assay.

09/11/2023

💥💥Oral Potentially Malignant Lesion Atlas Project 💥💥

MSMF has been the awarded the Oral Potentially Malignant Lesion Atlas Project by ICMR, a collaborative project to be carried out with KLE Institute of Dental Sciences, IISc, Homi Bhaba Cancer Hospital, and NCI AIIMS. The project was officially launched in July 2023 through a meeting in MSMF followed by the Oral Cancer Task Force Meeting organized by Biocon Foundation. The talks were delivered by key personnel from different collaborating centres, the industry partners such as Karkinos, and AIIndra.

Mazumdar Shaw Medical Foundation | MSMF TBI | Debprasad Dutta | Sujan Dhar | Amritha Suresh | Sumsum P Sunny | Kiran Vuppala | Narayana hrudayalaya | Atanu Ghorai

09/11/2023

💥💥Oral Cancer Task Force 💥💥

The Integrated Head and Neck Oncology program, MSMF is a part of the Oral Cancer Task Force, along with Biocon Foundation and KLE Institute of Dental Sciences, and has been effectively conducting multiple programs. A training program has been launched in collaboration as a part of the Oral Cancer Task Force, which aims to provide valuable insights into recent advancements and innovations in assessing the risk of oral cancer. This initiative has been ongoing since January, 2023. The training sessions are designed for various participants, including dental interns, general dentists, dental staff, entrepreneurs, dental postgraduate students, and engineering students. These training sessions occur for one week every month, with different batches of participants. They focus on educating individuals on the assessment of oral cancer risk using Dual Modality Imaging and AI, as well as Cytology. As of November 2023, we have successfully trained a total of 11 batches of participants.
Furthermore, we have also launched oral cancer screening camps at various Primary Health Centers (PHCs) and the Anekal Government Hospital. To date, a total of 64 patients have undergone screening for oral cancer through these camps.

Mazumdar Shaw Medical Foundation | MSMF TBI | Debprasad Dutta | Sujan Dhar | Amritha Suresh | Sumsum P Sunny | Kiran Vuppala | Narayana hrudayalaya | Atanu Ghorai

09/08/2023

📣 Mazumdar Shaw Medical Foundation News and Events : 📣
🏵 Segmentation and classifier for oral cytology images 🏵
MSMF scientists contribute towards developing a semantic segmentation model for Single Epithelial Cell (SEC) separation from fluorescent, multichannel, microscopic oral cytology images and classify the segmented images. The work, “Oral epithelial cell segmentation from fluorescent multichannel cytology images using deep learning”, published in Computer Methods and Programs in Medicine (https://www.sciencedirect.com/.../abs/pii/S0169260722005867), provided a pipeline for SEC segmentation that would enable automated, cytology-based early detection in oral cancer.

Mazumdar Shaw Medical Foundation | Debprasad Dutta| Sujan Dhar | Archana Ann J | Kiran Vuppala | Mazumdar Shawmf Foundation |
Atanu Ghorai | Sumsum P Sunny | Amritha Suresh