
29/04/2025
Case Study Highlight: Precision Diagnosis for CMV Retinitis Using Whole Metagenome Sequencing
At Dhiti Omics, we had the opportunity to assist in the diagnosis of a 26-year-old male, HIV-positive and on antiretroviral therapy, who presented with blurred vision in his left eye for two weeks.
He was clinically suspected of cytomegalovirus (CMV) retinitis — a potentially vision-threatening condition common among immunocompromised patients.
Using an aqueous humor sample, our team conducted comprehensive pathogen identification through our in-house Whole Metagenome Sequencing powered by the Nanopore platform.
Our findings:
Virus detected: Human beta-herpesvirus 5 (Cytomegalovirus)
No detection of bacteria, fungi, or parasites
No antimicrobial resistance (AMR) genes found
By leveraging unbiased, broad-spectrum sequencing — with no restriction to known pathogens — we provided clinicians with precise, actionable insights that helped guide targeted therapy and patient management.
At Dhiti Omics, we are committed to redefining infectious disease diagnostics through cutting-edge genomics technology.
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