28/07/2025                                                                            
                                    
                                                                            
                                            I am writing on behalf of all the investigators to share this exciting news that TOPSPIN main manuscript is published in Nature medicine (Impact factor – 50, one of the top journals in medicine). This is the first RCT of this big size to study the effect of various anti- hypertensives in Indian population. I am attaching the paper for your kind reference, and it can also be accessed from here - https://www.nature.com/articles/s41591-025-03854-w 
Thanks to CCDC , Dr Prabakaran sir and Dr Àmbuj Roy sir for leading the study from the front end!!
I thank our management and administration , the research team , my peers , all my co-investigators especially Dr Mohini Singh and Dr Meena Iyer for their full support. 
Being  the first RCT from India addressing an important public health problem, I take this opportunity to request you to share the results with all your friends and colleagues for the maximum reach.
Centre for Chronic Disease Control (CCDC) 
Dorairaj Prabhakaran 
Ambuj Roy 
Ambalam M Chandrasekaran 
                                                     
                                    
                                                                        
                                        To address an evidence gap for the efficacy of hypertension therapy using dual drug combinations in patients of South Asian origin, a randomized clinical trial conducted in India found that three types of dual drug combinations, each administered in a single pill, had similarly large effects on redu...