09/11/2025
Arterial and venous blood gases (ABGs and VBGs, respectively) help determine acid-base status, gas exchange, O₂ consumption, and electrolyte levels. Most of my patients in the OR and ICU have arterial lines for ABGs, but once these invasive monitors are removed, can VBGs still be helpful? 🤔
First, one must understand the path of blood flow and some basic physiology. Venous blood taken from the internal jugular vein via a central line will have a lower O₂ content because it drains the highly metabolically active brain, and therefore may not accurately represent the whole body. Peripheral VBGs can also be influenced by local factors, such as tourniquet application, which may alter pH, pCO₂, and pO₂ values. 😷
Arterial blood delivers oxygen to tissues; venous blood carries back CO₂, H⁺, and metabolic waste. If the venous end looks good, the arterial side is usually reassuring. For example, if a venous pH is 7.33 after tissue metabolism, I can expect a near-normal arterial pH. Similarly, a venous pCO₂ of 47 mmHg and a normal lactate typically indicate normal arterial counterparts; however, there are exceptions, such as cyanide toxicity, which can produce falsely reassuring venous pO₂ values. 💉
The evidence found that VBGs strongly correlate with ABGs for pH and bicarbonate (venous pH ≈ 0.04 lower, HCO₃⁻ ≈ 1 mEq/L higher), while pCO₂ agreement is variable, and pO₂ predictably differs due to oxygen extraction. Central venous samples can estimate ScvO₂ as a surrogate for mixed venous saturation (SvO₂) and allow calculation of the pCO₂ gap, a useful marker of cardiac output and perfusion. A gap greater than 6 mmHg suggests impaired flow or persistent shock, even when lactate levels normalize. 📈
Assuming the values for noninvasive SpO2 have been corroborated with an ABG beforehand, one can do a lot with a pulse ox and VBG! 🩸
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