28/03/2026
Dehydroepiandrosterone (DHEA) is an endogenous steroid hormone that serves as a precursor to estrogen and testosterone, both of which play important roles in ovarian function.
DHEA has been studied particularly in women with diminished ovarian reserve, where improving follicular recruitment and ovarian response is often challenging.
By influencing intra-ovarian androgen levels, DHEA may support early follicular development and improve ovarian responsiveness during IVF stimulation.
In clinical research published in peer-reviewed reproductive medicine journals, DHEA supplementation has been evaluated in women undergoing IVF, especially those with poor ovarian reserve.
In several studies, women received DHEA supplementation for a few weeks to months prior to IVF stimulation.
The outcomes were noteworthy:
• Improved ovarian response to stimulation
• Higher number of retrieved oocytes
• Increased mature oocyte yield
• Better embryo development in some groups
• Improved overall IVF cycle parameters
DHEA may support fertility by:
• Enhancing follicular recruitment
• Improving intra-ovarian androgen environment
• Supporting oocyte development
• Optimizing ovarian response to stimulation
Because follicular development begins weeks before stimulation, a preparation phase before IVF may help improve ovarian response in selected patients.
DHEA supplementation should always be used under medical supervision, as dosing and patient selection are important.
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DR MAHIMA KAK NAGPAUL
8700810088
[fertility counselling, infertility, DHEA, poor ovarian reserve, IVF preparation, ovarian response, egg quality, reproductive health, preconception counselling, Delhi, India]
References :
1.Dehydroepiandrosterone Supplementation in Women With Diminished Ovarian Reserve: A Systematic Review and Meta-Analysis – Reproductive Biology and Endocrinology, 2023
2.DHEA and Ovarian Response in Poor Responders Undergoing IVF – Human Reproduction, 2024