Apollo Medicine

06/04/2026

Tidal volume (TV) challenge improves the reliability of pulse pressure variation (PPV) in predicting fluid responsiveness. Our study evaluated whether carotid peak velocity (CPV) performs similarly.
In haemodynamically unstable patients, changes in CPV and PPV during a TV challenge (6 to 8 ml/kg) were assessed and compared with cardiac output response after fluid bolus.
Key Finding:
Changes in CPV variation predicted volume responsiveness similarly to changes in PPV following a tidal volume challenge.
This suggests CPV may serve as a useful non-invasive alternative for assessing fluid responsiveness in critically ill patients.

📖 Read the full article: https://doi.org/10.1177/09760016251328519
👨‍⚕️Authors:

Background and Aims: Tidal volume (TV) challenge was shown to improve the reliability of pulse pressure variation (PPV) in predicting volume responsiveness. Car...

01/04/2026

Large unstained cells (LUCs) are peroxidase-negative mononuclear cells that include large lymphocytes, plasma cells, blasts, and atypical lymphoid cells. Elevated LUC% on automated hematology analyzers can often indicate underlying hematological or infectious conditions.
Absolute LUC count (≥0.5 × 10³ cells/µL) may serve as a cost-effective and readily available marker for identifying clinically suspicious hematolymphoid neoplasms when interpreted with other CBC parameters. However, peripheral smear review remains essential for confirmation.

📖 Read the full article: https://doi.org/10.1177/09760016251327801
👨‍⚕️Authors:

Background and Aims: Large unstained cells (LUCs) are peroxidase negative mononuclear cells which include large lymphocytes in healthy individuals, peroxidase n...

27/03/2026

The manuscript review process in academic publishing is complex, and figures play a crucial role in communicating research findings effectively.
In our survey of clinicians, editors, and reviewers from imaging journals, 91.7% reported that figures are highly important in manuscripts. Original images and schematics were the most preferred figure types, and many respondents believed that combining schematics with original images could improve manuscript acceptance. However, the number of figures alone did not influence reviewer favourability. Concise, informative figure legends were also considered essential.
This study highlights that well-designed figures should complement methodological rigour and clear writing, helping improve reviewer perception and potentially increasing the likelihood of manuscript acceptance.
📖 Read the full article:

Background and Aim: The process of manuscript submission and review in academic publishing is multifaceted, with figures playing a crucial role in communicating...

23/03/2026

Central line-associated bloodstream infections (CLABSIs) remain a major challenge in healthcare, contributing to increased morbidity, mortality, and healthcare costs.
In our cross-sectional study across seven cardiac centres in Addis Ababa, we evaluated healthcare workers’ knowledge and practices related to CLABSI prevention. The study found that 85.8% of healthcare workers had good knowledge and 73.5% demonstrated good preventive practices. Factors such as higher education level, training, peer education participation, and work experience were significantly associated with better knowledge and practice.
These findings emphasise the importance of ongoing training programmes and continuous professional development initiatives to strengthen infection prevention strategies and improve patient safety in healthcare settings.
📖 Read the full article: https://doi.org/10.1177/09760016241310283
👨‍⚕️Authors:

Introduction: Preventing central line-associated bloodstream infections (CLABSIs) in healthcare settings reduces morbidity, mortality, and healthcare costs. Thi...

16/03/2026

Bronchogenic cysts are rare congenital anomalies—most often diagnosed in children and typically located within the thorax. Their occurrence in adults, especially in the neck, is exceptionally uncommon.
In our case report, a 51-year-old female presented with chronic mild throat pain for one year. Clinical examination was largely unremarkable, with only a subtle swelling on the right side of the neck on palpation. Radiological evaluation revealed a cystic lesion at the cricoid level.
Surgical excision was performed, and histopathological analysis confirmed a bronchogenic cyst.
This case highlights the importance of considering rare congenital lesions in the differential diagnosis of adult neck masses, even when clinical findings are subtle.

📖 Read the full article: https://doi.org/10.1177/09760016251341625
👨‍⚕️Authors:

Introduction: Bronchogenic cysts are a rare congenital anomaly. The majority of cases are reported in children, and they are extremely rare in adults. Extrathor...

13/03/2026

🧠 Pseudotumor Cerebri (PTC)—also known as benign intracranial hypertension—is a condition characterised by increased intracranial pressure, papilledema, optic nerve damage, and vision disturbances, despite the absence of a brain tumour.
A systematic review following PRISMA guidelines analysed over 12,000 patients, examining the diagnosis, surgical management, complications, and populations affected by Pseudotumor Cerebri and Idiopathic Intracranial Hypertension (IIH).
Understanding the causes and management of PTC is essential to prevent vision loss and improve patient outcomes.

📖 Read the full article: https://doi.org/10.1177/09760016251324358
👨‍⚕️Authors: G. Chmutin

Background and Aim: Pseudotumor cerebri (PTC), also called benign intracranial hypertension, is characterised by increased intracranial pressure (ICP), optic ne...

12/03/2026

Prediabetes is a prevalent condition in India. Dietary and lifestyle modifications provide the most efficacious intervention to halt the advancement of the illness. We performed a randomized controlled trial of a nutritional intervention, comparing the efficacy of rusk produced from finger millet, barley, and refined flour. The experiment lasted six months. At the conclusion of the study, we observed a significant reduction in fasting plasma glucose, postprandial plasma glucose and HbA1c levels in the finer millet and barley group. There were linked benefits in terms of increased hemoglobin and serum calcium levels without any substantial detrimental effects.

11/03/2026

Auditory Neuropathy Spectrum Disorder (ANSD) is a unique hearing condition where the cochlea’s outer hair cells function normally, but the transmission of sound signals from the ear to the brain is disrupted. This leads to significant difficulties in speech perception, especially in noisy environments, despite relatively preserved hearing thresholds.
A review of the literature highlights key aspects of ANSD, including its prevalence, etiopathogenesis, clinical features, diagnosis, and current treatment options. Risk factors such as prematurity, ototoxic medications, hyperbilirubinemia, and family history play an important role.
Importantly, because otoacoustic emissions (OAEs) and cochlear microphonics may appear normal in neonates, incorporating auditory evoked response testing in high-risk newborn screening is crucial to avoid missed diagnoses.
Early recognition and appropriate interventions—including hearing aids or cochlear implants when indicated—can significantly improve patient outcomes.

📖 Read the full article: https://doi.org/10.1177/09760016251316630
👨‍⚕️Authors:

Background and Aims: Auditory Neuropathy Spectrum Disorder (ANSD) is a condition that affects the auditory pathway, specifically the transmission of sound signa...

09/03/2026

Systemic autoimmune diseases can significantly affect renal function—but what happens when COVID-19 is added to the equation?
In our observational study conducted at Jawaharlal Nehru Medical College (Nov 2020–Oct 2021), we evaluated patients with systemic autoimmune diseases who developed acute kidney injury (AKI) during COVID-19.
⚠️ COVID-19 positivity, ICU admission, ventilatory support, inotropic support, haemodialysis, and low oxygen saturation were significantly associated with mortality.
• Need for ventilatory support emerged as an independent predictor of mortality.
These findings highlight the critical interplay between autoimmune disease, AKI, and COVID-19—underscoring the importance of early recognition and aggressive monitoring.

📖 Read the full article: https://doi.org/10.1177/09760016241311366
👨‍⚕️Authors:

Introduction: Systemic autoimmune diseases are known to have a significant impact on renal function, with varying degrees of severity that can influence overall...

07/03/2026

Cutaneous lymphomas are the second most common extra-nodal non-Hodgkin lymphomas, with mycosis fungoides (MF) being the most frequent primary type.
In our 10-year retrospective study, classified according to the latest WHO 2022 haematolymphoid tumour guidelines, we analysed cases with strong clinical and histological suspicion of cutaneous lymphoma.
🩺 Early recognition of specific histopathological patterns is crucial for accurate diagnosis and timely therapeutic decisions.

📖 Read the full article: https://doi.org/10.1177/09760016251323081
👨‍⚕️Authors:

Introduction: Cutaneous lymphomas represent the second most common extra-nodal non-Hodgkin lymphoma. Mycosis fungoides (MF) is the most common primary cutaneous...

05/03/2026

Antiphospholipid syndrome (APS) is characterised by persistent antiphospholipid antibodies (aPL) and clinical events such as thrombosis and pregnancy morbidity. While lupus anticoagulant (LA), anticardiolipin (aCL), and anti-β2 glycoprotein I (aβ2GPI) form the diagnostic cornerstone, growing evidence highlights the importance of non-criteria aPL—particularly antiphosphatidylserine-prothrombin (aPS/PT) antibodies.
🔬 Our prospective observational study (n=136) evaluated the correlation between LA and aPS/PT complex antibodies.
🔎 Conclusion:
aPS/PT antibodies, especially IgG, demonstrate meaningful correlation with LA and may enhance risk stratification in APS—supporting their potential role in refining laboratory assessment and thrombotic risk evaluation.

📖 Read the full article: https://doi.org/10.1177/09760016251323053
👨‍⚕️Authors:

Introduction: Antiphospholipid syndrome (APS) is typified by the development of antiphospholipid antibodies (aPL) that are persistently positive with the clinic...

02/03/2026

Optimising recovery from general anaesthesia is key to improving patient outcomes and operating room efficiency.
In our prospective, randomised, double-blinded study of 60 patients (ASA I–II) undergoing mastectomy under general anaesthesia, we compared Bispectral Index (BIS) monitoring with age-corrected MAC for assessing depth of anaesthesia using desflurane.
🔎 Conclusion:
BIS-guided anaesthesia offers earlier recovery with lower anaesthetic gas usage, making it a superior tool for monitoring depth of anaesthesia compared to corrected MAC.
Enhancing precision in anaesthesia delivery not only improves recovery but also promotes cost-effectiveness and patient safety.

📖 Read the full article: https://doi.org/10.1177/09760016251317277
👨‍⚕️Authors:

Background and Aims: To enhance recovery, we can use short acting agents and monitor depth of anaesthesia. Desflurane is less soluble in blood and has good emer...