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17/03/2020

First human trial of coronavirus vaccine begins in the US

The phase 1 trial to evaluate a candidate vaccine against the newly identified coronavirus, SARS-CoV-2, is taking place at the Kaiser Permanente research facility in Seattle, Washington.

Key Highlights

The vaccine, which is called mRNA-1273, contains a harmless genetic code copied from the virus that causes the COVID-19

Experts say the trial will take many months to determine the safety of the vaccine, as well as whether it can trigger an immune response in volunteers

The main purpose of the phase 1 clinical trial is to provide information about how the vaccine interacts with a healthy human body

Washington: Four healthy volunteers received a dose of an experimental coronavirus vaccine as the first human trial has started in the US. The trial to evaluate a candidate vaccine against the newly identified virus is taking place at the Kaiser Permanente Washington Health Research Institute (KPWHRI) in Seattle. The vaccine was developed by US National Institutes of Health (NIH) scientists and collaborators at biotechnology company Moderna Inc., based in Cambridge, Massachusetts.

A 43-year-old mother-of-two from Seattle became the first patient to receive the jab on Monday, March 17 2020, reported the BBC News, quoting news agency Associated Press. The researchers plan to enroll 45 participants ages 18 to 55 years in the trial. Experts say the trial will take many months to determine the safety of the vaccine, as well as whether it can trigger an immune response in volunteers. According to the researchers, the vaccine, dubbed mRNA-1273, cannot cause the coronavirus disease but contains a harmless genetic code copied from the virus that triggered the COVID-19.

“Finding a safe and effective vaccine to prevent infection with SARS-CoV-2 is an urgent public health priority,” NIAID Director Dr Anthony Fauci said in a NIAID statement, published March 16. Dr Frauci said this Phase 1 study, which was launched in record speed, is an important first step toward achieving that goal.

So, what is a ‘Phase 1’ trial?

For a new drug to be deemed safe and effective for widespread use, it must pass through three iterative phases of clinical trials. This means, if the initial tests go well, it may take at least 18 months before the vaccine becomes available for public use.

Basically, the phase 1 trial evaluates the safety and toxicity of a vaccine at different dose levels, as well as determines drug pharmacokinetics. The main purpose of the phase 1 clinical trial is to provide information about how the vaccine interacts with a healthy human body, according to the US Food and Drug Administration (FDA). During the first trial, the researchers will examine a small group of people, typically between 20 and 80 individuals, who would be administered different doses of an experimental treatment.

The phase 1 trial is led by Lisa A Jackson, M.D., senior investigator at KPWHRIl. The volunteers will be given two jabs into the upper arm muscle in total, with a 28-day gap between doses. Each participant will receive a 25 microgram (mcg), 100 mcg or 250 mcg dose at both vaccinations, with 15 people in each dose cohort.

"The first four participants will receive one injection with a low dose, and the next four participants will receive the 100 mcg dose. Investigators will review safety data before vaccinating the remaining participants in the 25 and 100 mcg dose groups and before participants receive their second vaccinations. Another safety review will be done before participants are enrolled in the 250 mcg cohort," said a news release by NIH.

The researchers will, over the course of a 14-month period, monitor how each person metabolises the given treatment and what common side effects emerge in response to different doses, LiveScience reported.

As per the US Centers for Disease Control and Prevention (CDC), after the phase 1 trial, the drug must then be tested in larger groups of people and over longer periods of time, in Phase 2 and Phase 3 trials.

Currently, there’s no approved vaccine exists that can help prevent infection with the coronavirus, which has claimed at least 7,007 lives and infected more than 175,530 people across the world. But, researchers around the world are working on various treatments to help combat the spread of the deadly virus which has triggered a global pandemic.
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14/03/2020

in India: 52 Authorised Centres Where You Can Get Tested for COVID-19**|FYIS:www.mediquickindia.com

In this article, we tell you what the test entails and the complete list of the 52 centers where the test for Covid-19 is being conducted.

How is the test for Coronavirus done?

**A swab test**: A sample from your throat or nose will be collected with the help of a cotton swab.

**A nasal aspirate**: In this method, the lab technician will inject a saline solution into your nose, and then remove the sample with a gentle suction.

**A tracheal aspirate**: A thin, lighted tube called a bronchoscope is inserted into your lungs, from where a sample is collected for testing.

**A sputum test**: Sputum can be collected either from the nose with a swab or by asking the patient to cough up the mucus.

**A blood test**: Blood sample is drawn and tested in a lab for the virus. This is either done through a blanket test for all variants of the coronavirus (including regular flu) or through a specialised gene-sequencing test that locates the marker for the novel coronavirus.

**Centers to Get Tested**

Andhra Pradesh:

Sri Venkateswara Institute of Medical Sciences, Tirupati
Contact number - +91-8772287777

Andhra Medical College, Visakhapatnam, Andhra Pradesh
Contact number - +91- 89127 12258

Government Medical College, Anantapur, AP
Contact number - +91 85542 49115

Andaman & Nicobar Islands:

Regional Medical Research Centre, Port Blair, Andaman and Nicobar
Contact number - 03192 251158/59

Assam

Gauhati Medical College, Guwahati
Contact number - 03612132751

Regional Medical Research Center, Dibrugarh
Contact number - 03732381494

Bihar

Rajendra Memorial Research Institute of Medical Sciences, Patna
Contact number - 06122636651

Chandigarh

Post Graduate Institute of Medical Education & Research, Chandigarh
Contact number - 01722747585

Chhattisgarh

All India Institute Medical Sciences, Raipur
Contact number - 07712572240

Delhi-NCR

All India Institute Medical Sciences, Delhi
Contact number - 01126588500

National Centre for Disease Control, Delhi
Contact number - 01123913148

Gujarat

BJ Medical College, Ahmedabad
Contact number - 07922680074

M.P.Shah Government Medical College, Jamnagar
Contact number - 02882553515

Haryana

Pt. B.D. Sharma Post Graduate Inst. of Med. Sciences, Rohtak, Haryana
Contact number - 01262211307

BPS Govt Medical College, Sonipat
Contact number - 01263 283 025

Himachal Pradesh

Indira Gandhi Medical College, Shimla, Himachal Pradesh
Contact number - 01772654713

Dr.Rajendra Prasad Govt. Med. College, Kangra, Tanda, HP
Contact number - 01892287187

Jammu and Kashmir

Sher-e- Kashmir Institute of Medical Sciences, Srinagar
Contact number - 01942401013

Government Medical College, Jammu
Contact number - 01912584247

MGM Medical College, Jamshedpur
Contact number - 06572360859

Karnataka

Bangalore Medical College & Research Institute, Bangalore
Contact number - 08026700810

National Institute of Virology Field Unit Bangalore
Contact number - 08026654084

Mysore Medical College & Research Institute, Mysore
Contact number - 08212520512

Hassan Inst. of Med. Sciences, Hassan, Karnataka
Contact number - 08172231699

Shimoga Inst. of Med. Sciences, Shivamogga, Karnataka
Contact number - 08182229933

Kerala

National Institute of Virology Field Unit, Kerala
Contact number - 04772970004

Govt. Medical College, Thriuvananthapuram, Kerala
Contact number - 04712528300

Govt. Medical College, Kozhikhode, Kerala
Contact number - 04952350216

Madhya Pradesh

All India Institute Medical Sciences, Bhopal
Contact number - 07552672322

National Institute of Research in Tribal Health (NIRTH), Jabalpur
Contact number - 07612370800

Meghalaya

NEIGRIHMS of Health and Medical Sciences, Shillong, Meghalaya
Contact number - 03642538013

Maharashtra

Indira Gandhi Government Medical College, Nagpur
Contact number - 07122725423

Kasturba Hospital for Infectious Diseases, Mumbai
Contact number - 022300432333

Manipur

J N Inst. of Med. Sciences Hospital, Imphal-East, Manipur
Contact number - 03852443144

Odisha

Regional Medical Research Center, Bhubaneswar
Contact number - 06742301322

Puducherry

Jawaharlal Institute of Postgraduate Medical Education & Research, Puducherry
Contact number - 04132271301

Punjab

Government Medical College, Patiala, Punjab
Contact number - 01752212018

Government Medical College, Amritsar
Contact number - 01832426918

Rajasthan

Sawai Man Singh, Jaipur
Contact number - 01412744283

Dr. S.N Medical College, Jodhpur
Contact number - 02912434374

Jhalawar Medical College, Jhalawar, Rajasthan
Contact number- 07432233388

SP Med. College, Bikaner, Rajasthan
Contact number - 01512220115

Tamil Nadu

King's Institute of Preventive Medicine & Research, Chennai
Contact number - 04422501520

Government Medical College, Theni
Contact number - 04546244502

Tripura

Government Medical College, Agartala
Contact number - 03812357130

Telangana

Gandhi Medical College, Secunderabad
Contact number - 04027505566

Uttar Pradesh

King's George Medical University, Lucknow
Contact number- 05222257540

Institute of Medical Sciences, Banaras Hindu University, Varanasi
Contact number - 05422367568

Jawaharlal Nehru Medical College, Aligarh
Contact number - 05712721165

Uttarakhand

Government Medical College, Haldwani
Contact number - 05946282824

West Bengal

National Institute of Cholera and Enteric Diseases, Kolkata
Contact number - 03323633373

IPGMER, Kolkata
Contact number - 03322041101

If you or anyone from your family needs to get tested, please visit one of the above-mentioned centers and do the needful.
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