30/12/2025
radiology, "panda sign" refers to different appearances, most commonly the "Face of the Giant Panda" on MRI for Wilson's disease, showing midbrain/pons changes, and the "Panda Sign" on Gallium-67 scans for sarcoidosis, showing lacrimal/parotid gland uptake. Another is the "Panda Cub Sign", also related to metabolic/toxic brain conditions, indicating specific signal changes in the pons and midbrain.
1. Face of the Giant Panda (MRI - Brain)
Condition: Traditionally associated with Wilson's disease (copper accumulation) but also seen in Leigh disease, Japanese encephalitis, methanol toxicity, etc.
Appearance: On T2-weighted MRI, it shows bright signals (hyperintensity) in the tegmentum of the midbrain and pons, with the sparing of the red nuclei creating "eyes," and the aqueduct/fourth ventricle forming the "nose/mouth".
2. Panda Sign (Gallium-67 Scan)
Condition: Most commonly sarcoidosis (inflammation).
Appearance: Increased uptake (appears "hot") in bilateral lacrimal and parotid glands, with normal uptake in the nasopharynx, resembling a panda's face.
Differential: Also seen in Sjögren's, lymphoma, AIDS.
3. Panda Cub / Double Panda (MRI - Brain)
Condition: Often seen with Wilson's or Leigh disease, depicting more detailed brainstem involvement.
Appearance: Involves the midbrain ("face") and the upper pons, with hyperintensities in the pontine tegmentum and cerebellar peduncles.