09/08/2025
Kunal Shah Tweets say
“Turns out at center of all lifestyle diseases is glucose spikes.”
You’re right that blood glucose spikes are increasingly recognized as a core driver—or at least a major aggravator—of many lifestyle-related diseases.
When glucose rises sharply (after a high-sugar meal, refined carbs, or certain eating patterns), it triggers a cascade of effects:
1. Insulin surges → cells pull in glucose, but frequent high spikes make cells resistant over time (insulin resistance).
2. Inflammation → high glucose promotes oxidative stress and inflammatory molecules.
3. Hormonal disruption → affects hunger/satiety signals, often leading to overeating.
4. Lipid changes → excess glucose gets converted to triglycerides, contributing to fatty liver and atherosclerosis.
These repeated spikes are linked to :
• Type 2 diabetes
• Cardiovascular disease
• Obesity
• PCOS
• Some neurodegenerative diseases
• Accelerated aging (via glycation damage to proteins)
Interestingly, it’s not just average glucose (A1C) that matters—glycemic variability (the size and frequency of spikes) may be just as important. Even people without diabetes can benefit from flattening those peaks.
