18/07/2025
New research shows childhood neglect literally rewires the brain. And it's a permanent change..
Childhood trauma doesn’t just shape memory—it reshapes biology.
arly adversity can permanently alter brain structure and immune system function. In a groundbreaking study led by Dr. Sara Poletti and published by Brain Medicine, scientists found that traumatic experiences during childhood can trigger chronic neuroinflammation—an immune response in the brain—that may increase lifelong vulnerability to psychiatric conditions such as depression, bipolar disorder, and anxiety disorders.
The findings suggest that these immune alterations may serve as biological markers, offering a path toward earlier diagnosis and targeted treatment for at-risk individuals.
Dr. Poletti's team combined neuroimaging, genetic analysis, and immunology to uncover how trauma imprints itself in the body.
Their work identified specific inflammatory markers linked to early adversity, laying the groundwork for precision medicine approaches in psychiatry.
Beyond clinical care, the research calls for broader societal shifts—such as trauma-informed policies and preventive interventions—to address the root causes of mental health disorders. With potential implications for everything from treatment strategies to public health frameworks, the study marks a turning point in understanding how deeply childhood trauma can shape both brain and body.
Source: Genomic Press Interview with Dr. Sara Poletti, Brain Medicine, June 12, 2025
