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30/04/2026

Humans may never need dentures again. 🦷 Researchers at Kyoto University Hospital in Japan have begun human trials for a drug designed to stimulate the growth of entirely new teeth. The drug targets a protein called USAG-1, which normally suppresses tooth development. By blocking this protein, the treatment reactivates dormant tooth buds, potentially triggering a third set of teeth. The first phase involves 30 healthy adult males aged 30 to 64, each missing at least one molar, with the study focused on safety and proper dosing. Dr. Katsu Takahashi, head of dentistry at the Medical Research Institute Kitano Hospital, confirmed that humans already carry a third set of tooth buds embedded in their mouths, waiting to be activated.

Human trials are being led by Toregem Biopharma, a biotech startup co-founded by Dr. Takahashi through Kyoto University, marking the world's first peptide-based attempt to regrow teeth in humans. 🔬 Preclinical results were already demonstrated successfully in mice and ferrets before moving to human subjects. Future trial phases will include children aged 2 to 7 born with congenital anodontia, a condition affecting roughly 1 percent of the global population. Imagine a child who never smiled freely finally growing their own teeth. 😮 If trials continue showing positive results, Toregem Biopharma anticipates commercial availability by 2030. Biology is rewriting the dental rulebook entirelyDashmesh dental cilnic

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29/04/2026

Dashmesh dental cilnic

28/04/2026

Scientists may have found a way to make damaged teeth repair themselves from the inside using a gel made from the same protein found in wool and human hair, and the results published in the International Endodontic Journal showed the material successfully triggered dental cells to start building new dentine tissue on their own. The gel is injectable through a needle, compatible with living cells, and slowly dissolves as new tissue grows in its place, making it one of the most promising early-stage materials ever tested for tooth regeneration. The specialized cells that build dentine responded at the optimal concentration by dramatically increasing calcium deposits, activating key growth genes, and producing the proteins that form real tooth structure. This discovery is still in the laboratory stage but it represents a genuine shift in how dentists and scientists are thinking about the future of dental care. Instead of filling a tooth with artificial material, the goal would be to guide your own cells to rebuild it. How different would your relationship with the dentist be if teeth could actually heal themselves?
Shared for information purposes only.
Source: International Endodontic Journal,
DOI: 10.1111/iej.12476Dashmesh dental cilnic

27/04/2026

Scientists found the bacteria that causes gum disease inside the brains of Alzheimer's patients — and the pattern of where that bacteria appears is challenging the assumption that Alzheimer's is a purely degenerative disease.
Porphyromonas gingivalis is the chief bacterial driver of periodontitis — the severe form of gum disease that affects the tissue and bone supporting the teeth. Researchers have repeatedly found this specific bacterium inside the brain tissue of people who died with Alzheimer's disease. That finding alone was striking. What followed made it more significant.
When researchers deliberately infected mice with Porphyromonas gingivalis, the animals rapidly developed key Alzheimer's pathology — including the buildup of amyloid-beta plaques, the protein deposits that characterize the disease in human brains.
The timeline of the infection adds another dimension. The bacteria's toxic enzymes have been detected in the brains of people showing early Alzheimer's changes years before memory loss or other recognizable symptoms appear. This suggests that if the bacteria plays a causal role, it may be initiating damage silently, long before the disease is clinically visible.
An experimental drug called COR388, developed by Cortexyme, has already shown success in lowering both bacterial load and amyloid-beta levels in preclinical models. Large human trials are still needed to establish whether this translates into meaningful treatment for people with Alzheimer's.
The research, published in Science Advances, does not prove that gum disease causes Alzheimer's in every case. It raises the serious possibility that at least some cases of the disease may have an infectious trigger — a fundamentally different mechanism than the purely degenerative model that has dominated Alzheimer's research for decades.
The practical implication, while research continues, is not complicated.
Oral health may matter more than medicine has previously emphasized. Brushing, flossing, and regular dental care are not just cosmetic habits.
They may be protecting considerably more than teeth."Dashmesh dental cilnic

22/04/2026

Hospital-acquired infections can be reduced by daily toothbrushing. Realising that many patients don't clean their teeth, researchers gave them toothbrushes – and pneumonia rates fell.Dashmesh dental cilnic

21/04/2026

Another Aligners delivered Dashmesh dental cilnic visit your provider for Illusion Aligners

19/04/2026

If your tooth pain feels worse at night, you’re not imagining it—there’s a real reason behind it.

When you lie down, blood flow to the head increases, raising pressure inside an already inflamed tooth. Because the dental pulp is enclosed in a small, rigid space, even a slight rise in pressure can intensify pain signals.

At the same time, pain becomes more noticeable at night. With fewer distractions and reduced sensory input, the brain focuses more on discomfort—making the toothache feel sharper and more persistent.

There’s also a circadian effect. Pain sensitivity tends to increase at night, and as the effects of pain relief wear off, underlying issues like pulp inflammation, deep decay, or infection become more evident.

This is more than just discomfort. Persistent or night-time tooth pain is often a sign of an underlying dental problem that needs timely evaluation.

Dashmesh dental cilnic

16/04/2026

Alzheimer’s & Your Mouth:

Yes… they’re connected 🧠🦷

Poor oral health mouth 👄 is linked to higher risk of Alzheimer’s disease.

—the connection is strong enough that researchers are seriously investigating it.

🧠🧠🧠🧠🦷🦷🦷🦷🧠🧠🧠🧠

🧪 What studies actually show

🦷 Gum disease = higher dementia risk

People with periodontitis (chronic gum infection) have a higher risk of developing cognitive decline and Alzheimer’s later in life.

📚 Large observational studies show:
⚠️ ~20–70% increased risk of dementia in people with severe gum disease

⸻

🦷 A sneaky bacteria 🦠shows up in the brain 👀🧠

One of the biggest findings:

🦠 Porphyromonas gingivalis (a major gum disease bacteria)
🧠 Found in the brains of Alzheimer’s patients
🧠 Detected in brain tissue post-mortem
🧠 Produces toxic enzymes called gingipains

📚 Study: Science Advances (2019)
Researchers found gingipain toxins in Alzheimer’s brains and suggested they may contribute to brain damage.

⸻

🦷 Inflammation is the bridge 🔥

Your mouth 👄is not “separate” from your body.

Gum disease → chronic inflammation → bloodstream 🩸→ brain🧠

This may:
🦠 Increase brain inflammation
🔺 Accelerate neuron damage
🧫 Worsen amyloid plaque buildup (a hallmark of Alzheimer’s ⚠️)

🧠🧠🧠🧠🦷🦷🦷🦷🧠🧠🧠🧠

Bad gums ≠ instant Alzheimer’s

But:

👉 chronic infection
👉 long-term inflammation
👉 possible bacterial spread

= higher long-term brain risk🧠🧫

⸻

🪥 The practical takeaway

Protecting your brain 🧠might start in your mouth👄🦷:

🪥 Brush + floss (yes, floss matters)
🪥 Treat gum bleeding early
🪥 Regular dental cleanings
🪥 Don’t ignore chronic bad breath or gum swelling

🧠🧠🧠🧠🦷🦷🦷🦷🧠🧠🧠🧠

🚪Your mouth is basically a “gateway organ.”

And science 🧪 is increasingly saying:

🦷 Healthy gums → lower inflammation → possibly healthier brain aging 🧠🫶🏻💪🏼Dashmesh dental cilnic

30/03/2026

A recent study highlights a strong mouth–body connection during pregnancy, showing that women with gum inflammation or periodontitis face almost double the risk of preterm birth or low-birth-weight babies.

Researchers suggest that bacteria and inflammatory molecules from infected gums can enter the bloodstream, potentially affecting the placenta and triggering early labor signals. Pregnancy hormones increase gum sensitivity, causing redness, bleeding, and tenderness, which can escalate into deeper gum inflammation that silently fuels systemic immune responses.

This condition is common, with up to 70% of pregnant women experiencing some form of gum inflammation. Health professionals now emphasize maternal oral care as a critical part of prenatal wellness, as maintaining healthy gums supports both pregnancy outcomes and newborn well-being.

(Source: Journal of Periodontology, 2026)Dashmesh dental cilnic

28/03/2026

Kissing isn’t just a gesture of affection it’s also a microscopic exchange. Research published in the Microbiome Journal found that a single 10-second kiss can transfer roughly 80 million bacteria between partners, effectively blending their oral microbiomes.

Couples who kiss about nine times daily develop saliva microbiomes that become remarkably similar, showing that love can literally synchronize the tiny ecosystems in our mouths. This exchange may also help train the immune system, exposing it to a broader range of microbes and potentially boosting resilience over time.

From sharing a moment of intimacy to subtly shaping our biology, kissing demonstrates how human connection can influence health in ways science is just beginning to understand.

Source: Kort, R. et al. Shaping the oral microbiota through intimate kissing. Microbiome 2, 41 (2014).Dashmesh dental cilnic

22/03/2026

Researchers in Japan have uncovered a hidden layer of genetic complexity in the human mouth: giant extrachromosomal DNA elements called Inocles. Found in the common bacterium Streptococcus salivarius, these massive DNA structures measure around 350 kilobase pairs, far larger than typical plasmids, and carry genes linked to stress adaptation, DNA repair, and damage resistance.

By using long-read sequencing combined with a new method called preNuc, which removes human DNA from saliva, the team reconstructed complete Inocle genomes for the first time. Their findings suggest that nearly three-quarters of people worldwide harbor these elements in their oral bacteria. Inocles may give bacteria greater resilience, influencing oral health conditions such as cavities, gum disease, and potentially cancer.

Lead author Yuya Kiguchi (University of Tokyo) noted that Inocles went undetected for decades due to technological limits. Future research will focus on culturing Inocle-containing bacteria to explore their roles and evaluate whether these giant DNA elements could serve as biomarkers for human health.

(Source: Nature Communications, 2025)Dashmesh dental cilnic

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