Unit Head,Nephrology at Artemis Health Institute,Gurgaon

26/09/2025

20/09/2025

Chronic Kidney Disease, or CKD, is a condition that damages your kidneys over time. Your kidneys have many important roles, including blood filtering and red blood cell production. Once kidneys fail, dialysis or a kidney transplant is needed to stay alive.

While 1 in 7 are estimated to have CKD, only 10% of those with CKD are aware that they have it. Discuss your kidney health with your doctor at your next appointment!

Learn more about CKD, including risk factors and symptoms: https://www.kidney.org/.../about-chronic-kidney-disease

20/09/2025

❤️💙 The Heart–Kidney Connection 💙❤️
Exploring the Cardio Bioregulator Peptide

Did you know? 👀
The two most common causes of chronic kidney disease (CKD), high blood pressure & diabetes, are also leading risk factors for heart disease.

Your kidneys 🧩 and heart ❤️ are deeply interconnected:

🩸 Kidneys regulate blood pressure by managing fluid & sodium levels

💔 Heart disease is the #1 killer in people with CKD

🔄 When the heart weakens, kidney blood flow drops → less oxygen & nutrients → kidney damage

⚠️ The body compensates by activating the renin-angiotensin-aldosterone system (RAAS), which retains sodium & water. While this helps short-term, it worsens heart failure long-term.

🚨 Poor heart function = reduced kidney perfusion

🚨 Poor kidney function = increased heart strain (fluid overload, electrolyte imbalance, toxins)

It’s a vicious cycle 🌀 … but understanding this heart–kidney link opens the door for new therapies, like the Cardio Bioregulator Peptide, to help restore balance.

💭 Did you know your kidneys and heart were this connected?

20/09/2025

🩸 Your Blood Vessels & Kidneys: A Vital Connection 💥

Did you know your kidneys are packed with tiny blood vessels, especially in the glomeruli, where blood is filtered?

When the endothelial cells lining these vessels become damaged or dysfunctional, it creates a ripple effect that can accelerate the progression of kidney disease. 🚨

🔍 What Happens?
Damaged endothelial cells =
⚠️ Increased permeability
⚠️ Proteinuria (protein leaking into urine an early warning sign)
⚠️ Reduced filtration efficiency

🌬️ Enter Nitric Oxide (NO)
Healthy endothelium makes nitric oxide, which helps:
✅ Dilate blood vessels
✅ Improve circulation
✅ Maintain glomerular filtration

But in chronic kidney disease (CKD):
❌ NO production drops
❌ Vasoconstrictors like endothelin-1 rise
➡️ Result = narrowed vessels, poor kidney perfusion, and worsening damage

🧠 Protecting your endothelial health = protecting your kidneys.

20/09/2025

29/08/2025

29/08/2025

🧬 Endothelial Health & Kidney Disease: The Vicious Cycle Continues 🩸🧠

In our previous post, we examined how endothelial damage impacts kidney function. But here’s where it gets more serious 👇

🔥 Inflammation
When endothelial cells are damaged, they become pro-inflammatory, expressing “adhesion molecules” that attract immune cells.

This drives:

Glomerulosclerosis (scarring of the kidney filters)

Tubulointerstitial fibrosis (damage between the tubules)
➡️ Result: progressive loss of kidney function

🩸 Clotting Complications
Dysfunctional endothelium becomes pro-thrombotic, encouraging small clots in delicate kidney vessels.

🔻 This can trigger acute kidney injury and speed up CKD progression.

♻️ The Bidirectional Storm
Kidney disease → worsens endothelial health
AND
Endothelial dysfunction → worsens kidney disease

This loop is driven by:

Uremic toxins

Altered mineral metabolism

Chronic inflammation

⚠️ The kicker? This cycle raises your cardiovascular risk, too. And that's something we want to interrupt early.

29/08/2025