29/04/2026
“Stopped Ozempic… Why is my weight coming back?”
Many people lose about 15 kg while taking weight‑loss injections like Ozempic / Wegovy / Zepbound.
After stopping them, they often gain back around 10 kg within 1 year – almost 2/3rd of the weight they lost.
This weight comes back much faster than with diet and exercise alone.
What is this new “gut reset”?
Doctors are testing a new endoscopy procedure called Duodenal Mucosal Resurfacing (DMR).
It is done through the mouth with an endoscope, as a day‑care procedure – no cuts on the stomach.
Using gentle heat, the doctor removes the top layer of the duodenum (first part of small intestine) so that a fresh, healthy lining grows back.
Why do this?
The duodenum talks to your hormones and metabolism – it helps control sugar, hunger, and how the body handles food.
By “resetting” this area, DMR may help the body keep weight and sugar under better control even after stopping GLP‑1 injections.
What have early studies shown?
In early studies, people who stopped GLP‑1 injections and also had DMR:
Gained back less weight than those who did not have the procedure.
Were able to keep most of their weight loss for several months.
This “gut reset” is not a magic cure.
It is a new, still‑experimental endoscopic option that may help people keep their weight loss after stopping injections.
Healthy food, regular activity, sleep, and medical follow‑up will always remain the most important part of long‑term weight control.