07/03/2025
Analgesics and your kidneys
Many analgesic medicines (pain relievers) are available over the counter. These medicines are generally safe when taken as directed. However, their heavy or long-term use may harm the kidneys. Up to an estimated three to five percent of the new cases of chronic kidney failure each year may be caused by chronic overuse of these medicines. It is important to realize that, while helpful, these medicines are not completely without risk, and they should be used carefully. Kidney disease related to analgesics is preventable.
What are analgesics?
Analgesics are medicines that help to control pain and reduce fever. Examples of analgesics that are available over the counter are: aspirin, acetaminophen, ibuprofen, ketoprofen and naproxen sodium. Some analgesics contain a combination of ingredients in one pill, such as aspirin, acetaminophen and caffeine.
Can analgesics hurt kidneys?
Generally, when used according to directions, over-the-counter analgesics are safe. However, heavy or long-term use of these medicines, especially those that contain a mixture of painkilling ingredients--such as aspirin, acetaminophen and caffeine--in one pill, have been linked to chronic kidney disease in European studies. The warning labels on over-the-counter analgesics tell you not to use these medicines more than 10 days for pain and more than three days for fever. If you have pain and/or fever for a longer time, you should see your doctor. The doctor can check for possible medical problems and advise you about what medications you should take.
Is aspirin safe for regular use?
When taken as directed, regular use of aspirin does not seem to increase the risk of kidney disease in people who have normal kidney function. However, taking doses that are too large (usually more than six or eight tablets a day) may temporarily reduce kidney function. In people with kidney disease, aspirin may increase the tendency to bleed. People who already have reduced kidney function, or other health problems such as liver disease or severe heart failure, should not use aspirin without speaking to their doctor.