Dr. Vinod Kumar Jangir - Expert General Physician & Sonologist

09/02/2026

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19/01/2026

13/01/2026

13/01/2026

Teplizumab is a humanized anti-CD3 monoclonal antibody used in type 1 diabetes (T1D) to delay disease progression by modulating the immune response.

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🔬 Mechanism of Action
• Targets CD3 receptor on T lymphocytes
• Induces partial T-cell exhaustion and immune tolerance
• Reduces autoreactive T-cells attacking pancreatic β-cells
• Preserves residual insulin secretion

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🩺 Clinical Use (FDA-Approved)

Indication
• Delay onset of Stage 3 Type 1 Diabetes
• In high-risk individuals (Stage 2 T1D):
• ≥2 positive pancreatic autoantibodies
• Dysglycemia but not yet insulin-dependent

Who Benefits Most
• First-degree relatives of T1D patients
• Children and adolescents (≥8 years)
• Recently diagnosed autoimmune diabetes (early stage)

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💉 Administration
• IV infusion for 14 consecutive days
• Dose escalation over initial days to reduce cytokine release

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📊 Key Evidence

TrialNet Study
• Median delay of ~2 years in progression to clinical T1D
• Some patients delayed >5 years
• Improved C-peptide preservation

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⚠️ Adverse Effects

Common:
• Flu-like symptoms
• Rash
• Headache
• Nausea

Important:
• Transient lymphopenia
• Elevated liver enzymes
• Cytokine release syndrome (usually mild–moderate)

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🧪 Monitoring
• CBC with differential
• Liver function tests
• EBV/CMV status (baseline)
• Blood glucose and HbA1c

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💊 Trade Name
• Tzield®️ (by Provention Bio / Sanofi)

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🌍 Status in India
• Not yet widely available
• No CDSCO approval as of now
• Access mainly via clinical trials or compassionate use

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🔮 Future & Research Directions
• Combination therapy (e.g., with anti-IL-21, low-dose IL-2)
• Use in LADA and newly diagnosed T1D
• Personalized immunotherapy using immune profiling

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🧠 Take-home Message

Teplizumab is the first disease-modifying immunotherapy in T1D that delays clinical diabetes, shifting management from treatment to prevention.

13/01/2026

Taplizumab

24/09/2024

🤔 Why Choose Us?
🔹 Trusted by thousands for accurate diagnoses
🔹 Cutting-edge ultrasound technology for precise results
🔹 Personalized care tailored to your health needs
🔹 Compassionate team dedicated to your well-being

Experience the difference with expert sonology services! Book your appointment today! 💙

16/09/2024

🌟 Free Medical Health Checkup Camp – A Success! 🌟

We are thrilled to announce the successful completion of our Free Medical Health Checkup Camp, where 80 patients were diagnosed with the care and precision they deserve!

Under the leadership of Dr. Vinod Jangir, our dedicated medical team worked tirelessly to provide essential diagnostic services, including ultrasound screenings, blood pressure monitoring, diabetes testing, and more. Our goal was to ensure that each patient received timely and accurate health assessments, empowering them to take charge of their well-being.

🏥 Highlights of the Camp:

Comprehensive health assessments for 80 patients
Expert consultations with our experienced medical professionals
Early detection of potential health issues
Personalized health advice and follow-up plans
We’re committed to continuing our efforts in promoting community health and wellness. Thank you to everyone who participated and made this camp a success!

Together, we strive for a healthier tomorrow. Stay tuned for more upcoming initiatives!

09/09/2024

Say Goodbye to High Blood Sugar with This Miracle Roti!

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Transform your meals with this game-changing low-carb roti, perfect for managing blood sugar levels! 🌟 By incorporating bottle gourd into your dough, you’re creating a nutritious, diabetic-friendly option that’s both tasty and healthy. Watch our step-by-step video to learn how to make this special roti and start enjoying guilt-free, balanced meals today! 💪

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