05/02/2026
Molecular Hydrogen Therapy (MHT) exerts cytoprotective effects in the brain primarily through its selective scavenging of highly toxic reactive oxygen species, thereby reducing oxidative neuronal injury without disrupting physiological redox signaling.
By stabilizing mitochondrial function, MHT preserves ATP generation, limits apoptosis, and supports neuronal survival during ischemic, hypoxic, and inflammatory stress.
In terms of neurovascular health, hydrogen improves endothelial function by attenuating vascular oxidative stress, enhancing nitric oxide bioavailability, and maintaining blood–brain barrier integrity.
These effects collectively contribute to improved cerebral microcirculation and reduced neuroinflammation, which are critical for preventing secondary neuronal damage.
Overall, MHT supports brain resilience by integrating neuronal cytoprotection with vascular protection, thereby promoting long-term neurovascular homeostasis and functional recovery.
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