Oral & Maxillofacial Pathology titbits.

22/01/2026

Paraneoplastic condition

19/01/2026

AOMPB meet 2026

12/01/2026

07/01/2026

Clinical testing has begun on a new drug that can stimulate the regrowth of human teeth in as little as four days.

Researchers have started human trials for a revolutionary treatment that encourages teeth to grow back naturally, a development that could one day replace the need for dentures and dental implants.

For generations, losing permanent teeth was viewed as an irreversible consequence of aging, trauma, or disease, forcing millions of people to rely on artificial replacements. Scientists at Kyoto University are now overturning that assumption by testing a drug that activates the body’s own ability to regenerate teeth. The therapy works by suppressing a protein known as USAG-1, which normally prevents dormant tooth buds from developing. When this protein is blocked, animal studies have shown the growth of new, fully functional teeth, revealing the existence of a hidden “third set” of teeth that humans carry but never naturally activate.

The research is being developed by the biotech startup Toregem BioPharma, with early trials focusing on patients born with tooth agenesis, a condition in which adult teeth fail to develop. These individuals are considered ideal candidates because their tooth buds already exist but remain inactive. Although the treatment depends on precise biological timing to be effective, its success could transform restorative dentistry. Instead of relying on synthetic materials like porcelain or titanium, future dental care may harness the body’s own regenerative potential to rebuild natural teeth.

Source: Takahashi, K., Kiso, H., & Murashima-Suginami, A. Advances in tooth agenesis and tooth regeneration. Regenerative Therapy.

06/01/2026

17/12/2025

For educational purpose

17/12/2025

Take a look on another commonly encountered anatomical variation; sublingual varices.
Sublingual varices are abnormally dilated and tortuous veins, commonly observed in older adults, as multiple bluish blebs on the ventral and lateral borders of the tongue.
They probably represents an age-related degeneration, manifested by weakening of blood vessel walls and tone loss in the supporting connective tissue.
Other suggested etiologic factors include smoking, cardiovascular disease, and hypertension.
Sublingual varices are typically asymptomatic, and no treatment is indicated.

08/09/2025

Seminar on salivary pathology org by AOMPB…