Chromatin Dynamics Laboratory

11/09/2025

🌟 Heartiest Congratulations to Prof. Chandrima Das on being elected as a Fellow of the Indian National Science Academy (INSA)! 🌟

Her pioneering contributions in unraveling the connections between the epigenome, cancer, matrix remodeling, and immune signaling have been truly inspiring. We, her students, are proud to celebrate this prestigious recognition and fortunate to learn under her guidance. 🙌

04/09/2025

We are happy to share our most recent study, "The Hypoxia-Induced Chromatin Reader ZMYND8 Drives HIF-Dependent Metabolic Rewiring in Breast Cancer," which was published in JBC. In this study, we examined how the epigenetic factor ZMYND8 contributes to the metabolome rewiring of breast cancer. Our finding suggests that epigenetic factors in cancer cells can modulate the tumor microenvironment by modulating the metabolic status of cancer cells.
Many congratulations to Sandhik and Atanu for successfully steering the project towards completion. Congratulations to Indrakshi and Wasim for their contribution to this work.
Link to the online article: https://www.jbc.org/article/S0021-9258(25)02532-3/fulltext

04/04/2025

We are happy to announce our latest publication of Dr. Audesh Bhat, Ms. Sonali Bhan, Ms. Aindrila Kabiraj, Dr. Raj K. Pandita, Dr. Keneth S. Ramos, Mr. Sandhik Nandi, Ms. Shreya Sopori, Dr. Parthas S. Sarkar, Mr. Arti Dhar, Ms. Shruti Pandita, Dr. Rakesh Kumar, Dr. Chandrima Das, Dr. John A. Tainer, and Dr. Tej K. Pandita entitled “𝐀 𝐩𝐫𝐞𝐝𝐢𝐜𝐭𝐢𝐯𝐞 𝐜𝐡𝐫𝐨𝐦𝐚𝐭𝐢𝐧 𝐚𝐫𝐜𝐡𝐢𝐭𝐞𝐜𝐭𝐮𝐫𝐞 𝐧𝐞𝐱𝐮𝐬 𝐫𝐞𝐠𝐮𝐥𝐚𝐭𝐞𝐬 𝐭𝐫𝐚𝐧𝐬𝐜𝐫𝐢𝐩𝐭𝐢𝐨𝐧 𝐚𝐧𝐝 𝐃𝐍𝐀 𝐝𝐚𝐦𝐚𝐠𝐞 𝐫𝐞𝐩𝐚𝐢𝐫” published in the along with another article from our lab ' https://doi.org/10.1016/j.jbc.2025.108271 ' in the same issue (Volume 301, Issue 3) of the journal.
The article considers connecting chromatin organization to functional outcomes impacting transcription, DNA repair, and genomic integrity as an emerging grand challenge for predictive molecular cell biology.

Direct access link:
https://doi.org/10.1016/j.jbc.2025.108300
We are grateful to everyone for their respective contributions to the study's objectives.

04/04/2025

We are happy to announce our latest publication of Ms. Sinjini Dhang and Mr. Atanu Mondal entitled “Metformin inhibits the histone methyltransferase CARM1 and attenuates H3 histone methylation during gluconeogenesis,” published in the .
The article depicts how the well-known drug metformin inhibits the epigenetic regulator CARM1, leading to a reduction in histone methylation. This process subsequently suppresses gluconeogenic genes, resulting in decreased glucose production in the liver.
We are delighted to share the cover art that has been selected for the publication in the Journal has been created by Atanu Mondal.
Direct access link:
https://doi.org/10.1016/j.jbc.2025.108271

We are grateful to Dr. Siddhartha Roy and Dr. Chandrima Das for their important contributions to the study's objectives.

03/04/2025

We are happy to announce our latest publication of Mr. Atanu Mondal ,Mr. Sandhik Nandi, and Dr. Vipin singh, Mr. Arnab Chakraborty, Ms. Indrakshi Banerjee, Dr. Sabyasachi Sen, entitled “TCF7l2 Regulates Fatty Acid Chain Elongase HACD3 during Lipid-Induced Stress” published in the journal .
We are delighted to share the cover art that has been selected for the publication in the Journal

Direct acess link:

https://doi.org/10.1021/acs.biochem.4c00491

We are grateful to Dr. Shrikanth S Gadad, Dr.Siddhartha Roy, Dr. Siddhesh S Kamat,and Dr. Chandrima Das and for their important contributions towards the study's objectives.

28/01/2025

Happy times are here again..
We are happy to share that our 7th graduate student of CDL, Mr. Vipin Singh has completed his journey and successfully defended his thesis. All the best for his future endeavors...
Congratulations once again to him...

15/01/2025

Happy times are here again..
We are happy to share that our 6th graduate student of CDL, Ms. Swagata Adhikari has completed her journey and successfully defended her thesis. All the best for her future endeavors...
Congratulations once again to her...

12/01/2025

Congratulations to Bipasa and Sandhik for their achievements for the best performer award in Post M.Sc. course work in the academic year 2023-2024 (August - July) and 2022 (January-December) respectively.

12/01/2025

Chromatin Dynamics Lab celebrating the 75th foundation day of Saha Institute of Nuclear Physics

01/07/2024

Our latest publication in the journal of BBA-Gene Regulatory Mechanism focuses on a very dynamic post-translational modification called ubiquitination, which impacts DNA replication, repair, and transcription. The review elucidates the intricate orchestration of histone ubiquitination impacting diverse cellular functions and disease pathogenesis and provides insights into the current challenges of targeting them for therapeutic interventions.

We congratulate our collaborators Dr. Anirban Dasgupta, Mr. Sayan Gupta, and Prof. Siddhartha Roy, and our pre-doc student Mr. Sandhik Nandi along with Prof. Chandrima Das for the publication.

Cheers to all...!!

01/07/2024

One of our latest publications is a book chapter by our pre-graduate students Mr. Sandhik Nandi, and Mr. Atanu Mondal, and one of the prosperous dissertation students Mr. Aritra Ghosh, which was published in the prestigious Journal of Advances in Cancer Research.

The book chapter dealt with mostly the non-coding part of the genome and mainly focused on lncRNAs, which regulate various physiological processes and have been reported to be involved in several human pathologies ranging from neurodegenerative disease to cancer. The chapter categorically portrayed the role of significant lncRNAs in the outcomes of cancer drug resistance.

We thank the insightful help and constructive suggestions of Dr. Shravanti Mukherjee in this study.

01/07/2024

We are happy to announce our latest publication of Mr. Vipin Singh, Mr. Sandhik Nandi, and Dr. Santanu Adhikary on the Epigenetic reprogramming of T cells, that got published in the prestigious journal of .

In this study, it has been shown that T cells, crucial in cancer immunotherapy, undergo various histone modifications and DNA methylation changes. This review explores epigenetic mechanisms in cancer immune response and their role in resistance. Understanding T cell epigenetic regulation could lead to innovative strategies to overcome drug resistance and improve cancer immunotherapy efficacy.

We are grateful to Dr. Siddhartha Roy, and Dr. Shravanti Mukherjee for their important contributions towards the study's objectives.

T cells, a key component of cancer immunotherapy, undergo a variety of histone modifications and DNA methylation changes since their bone marrow progenitor stages before developing into CD8+ and CD4+ T cells. These T cell types can be categorized into distinct subtypes based on their functionality a...