13/09/2025
Cardiorespiratory Exercise: A Promising Strategy for Sharpening Cognition After Stroke
The positive impact of cardiorespiratory exercise on the brain is multifaceted and involves several key biological mechanisms:
Improved Cerebral Blood Flow: Aerobic exercise enhances blood circulation throughout the body, including the brain. This increased blood flow delivers more oxygen and essential nutrients to brain cells, which can aid in the repair and recovery of brain tissue damaged by the stroke.
Neuroplasticity and Neurotrophic Factors: Physical activity is known to stimulate the production of brain-derived neurotrophic factor (BDNF), a protein that plays a crucial role in the survival, growth, and differentiation of neurons. Higher levels of BDNF are associated with enhanced learning, memory, and overall cognitive function, promoting the brain's ability to reorganize and form new neural connections—a process known as neuroplasticity.
Reduced Inflammation and Oxidative Stress: Stroke can trigger inflammatory processes and oxidative stress in the brain, which can lead to further neuronal damage. Regular exercise has anti-inflammatory effects and can help to reduce oxidative stress, thereby protecting the brain from secondary injury.
Preservation of Brain Volume: While some recent studies have shown mixed results on whether cardiorespiratory exercise can prevent the loss of overall brain volume after a stroke, there is evidence to suggest it may help in preserving specific, crucial areas of the brain.