29/04/2020
Immunity: Understanding the Science of bovine Immunoglobulins
Dr. Rajesh Grover, leading Immunologist and Biomedical expert, explains how antibodies protect our bodies from pathogens and viruses and why bovine antibodies in colostrum are effective.
Where did immunity arrive? Immunity arrived as a result of the challenges posed by the pathogens
and the microbes. Fast forward, the first adaptive immune system arrived in this fish called Agnathans. This was around 600 million years ago and that's where the first antibody was formed. Today there are 5,416 species of mammals and all of them have different kinds of antibodies. We have our own antibodies that actually help protect us. There are a hundred million different combinations of antibodies floating around in our blood and this is the same principle used for vaccination. For example, there are three kinds of vaccination processes through which humanity has so far protected ourselves as a species. When you inject the immunogen, your body actually launches an immune response and the immune response is making antibodies specific to that antigen and it prepares your body for future encounters. This is one way of protecting, but the other way of doing it is called passive immunization.
In other words, so you can actually inject antibodies from outside and protect your body. Antibodies can work in two different ways: 1) Protect against the pathogens it can tag or 2) it can bind in such a manner that it can actually deactivate the biological role of that pathogen. For example, if it attaches to the virus, virus cannot attach to the cells. [The] antibody molecule is a Y shaped molecule and it's binding works through its head. There are loops that are made out of amino acids. These loops are used by the antibodies to bind to their target antigen. It can be a microbe, a bacteria, parasite, [or] virus. In humans it is 15 amino acids, whereas in cows it's actually 40 to 60 amino acids. Out of 5,416 mammals, [the] cow has the largest loop. In other words, cows are very effective in fighting any viruses, bacteria, or pathogens because of the size of the loop. In mammalian evolution, the first milk produced by the mother has a very potent mixture of immunoglobulins.
For example, colostrum has been used for ages by humans to actually protect our own bodies. How does it work? So colostrum is full of protective antibodies and as I mentioned, the cow antibodies are so unique because of the big loops that can actually explore the huge surface area. Microorganisms [like] viruses from cows and humans have cross-reactivity. For example, there is a virus called bovine coronavirus. If [the] cow gets Bovine Coronavirus, that cow will make antibodies against that Coronavirus. Now, these antibodies may actually react with human Coronavirus. When liposomal-coated colostrum bypasses the stomach, it gets into your small intestine. 15% of them will get into the blood and cow antibodies have a huge surface area in their binding region. They can actually bind to viruses if you have viruses in your gut and actually incapacitate them. This recent issue with CoVID-19 Coronavirus is quite interesting in the sense that it is a respiratory virus.
It actually goes through the respiratory system, but it has also been found that it might be going directly through your gut and infecting the system or the body through that route. Now, for example, if you take colostrum, this colostrum that has potential binding elements for this Coronavirus can bind into the gut and prevent this Coronavirus from actually getting into your bloodstream. The key here is that [this is] how viruses infect [the] human body. They have to bind to the human cells in order to cause the damage. Viruses cannot multiply on their own. For them to multiply they need host cells. If the cow antibody can actually bind to that Coronavirus, that Coronavirus will not be able to attach to the mammalian cell, and hence it will save the human body.
![Boost your Immunity power with AVCOLO [Bovine Colostrum]](https://img3.findhealthclinics.com/926/985/513873609269854.jpg)
