19/12/2025
Kidney Cancer (Renal Cell Carcinoma):
What You Need to Know
Kidney cancer, most often renal cell carcinoma (RCC), is when cells in the kidney grow out of control.
It's one of the top 10 cancers in adults, and catching it early makes a big difference.
As a urologist, I see many patients worried about this—let's break it down in easy language, with what causes it, symptoms, tests, treatments, and follow-up.
What Causes Kidney Cancer?
No one thing "causes" it, but certain risks make it more likely:
• Smoking
• Being overweight: Extra weight stresses the kidneys.
• High blood pressure: Long-term hypertension is a key risk.
• Family history or genetic conditions (like von Hippel-Lindau syndrome).
• Long-term kidney problems or dialysis.
• Exposure to certain chemicals (rare).
In India, rising cases link to lifestyle changes like obesity and diabetes.
How It Develops:
Cancer starts when kidney cells' "instructions" (genes) go wrong.
The most common type (clear cell) often involves a gene called VHL not working properly, causing new blood vessels to grow and feed the tumor.
Over time, the cancer can spread to lungs, bones, or lymph nodes if not caught early.
Signs and Symptoms:
Listen to Your Body
Many people have no symptoms early on—it's often found during checks for other issues. Watch for:
• Blood in urine (pink, red, or cola-colored).
• Pain in the side or back that doesn't go away.
• A lump you can feel in the belly.
• Feeling tired, losing weight without trying, or fever.
• Swelling in legs or ankles.
If you notice these, don't wait—see a doctor.Tests and DiagnosisDoctors use:
• Ultrasound or CT scan: Best way to see the tumor.
• Blood and urine tests: Check kidney function and look for blood.
• Biopsy (sometimes): Taking a small sample to confirm cancer.
Staging tells how far it's spread (Stage 1 is small and confined; Stage 4 has spread).
Treatment Options:
Tailored to You
Treatment depends on size, stage, and your health:
• Surgery: Often the main cure.
• Partial nephrectomy: Remove just the tumor, save the rest of the kidney (preferred when possible).
• Radical nephrectomy: Remove the whole kidney (if tumor is large).
• Done laparoscopically or robotically for faster recovery.
• Ablation: Freeze or heat the tumor for small ones (cryotherapy or radiofrequency).
Medications for Advanced Cancer:
• Targeted drugs (like sunitinib, pazopanib) block tumor blood supply.
• Immunotherapy (nivolumab, pembrolizumab) boosts your immune system to fight cancer.
• Combinations often work best now.
• Radiation: Rarely for kidney, but for bone pain if spread.
In India, access to robotic surgery and newer drugs is growing in major centers.
Alternative Therapies
No alternative replaces standard treatment, but some help with side effects:
• Yoga/meditation for stress and energy.
• Acupuncture for pain/nausea.
• Diet rich in fruits/veggies for overall health.
Always discuss with your doctor—some herbs can interfere with meds.
Long-Term Follow-Up and Handling Recurrences , After treatment:
• Regular scans/tests every 3–6 months first, then yearly.
• Watch for new symptoms—recurrence happens in 20–30% cases, often lungs/bones.
• If returns: More surgery, targeted drugs, or immunotherapy.
Special cases:
• Multiple tumors in one kidney: Often genetic—save as much kidney as possible.
• Hereditary syndromes (e.g., VHL): Regular screening from young age; special drugs like belzutifan for some.
Kidney cancer is serious but treatable, especially early.
Lifestyle (quit smoking, healthy weight) lowers risk. If worried, get checked—simple tests can save lives.
Reach out—early action matters!
Dr Bivek Kumar - Urologist
Urologist & Andrology Specialist,
SPARSH Hospital, Bangalore
https://www.sparshhospital.com/doctors/dr-bivek-kumar/