02/02/2026
GL Sciences Inertsil Hybrid-C18.
Inertsil Hybrid-C18 was newly developed to meet the evolving needs of users, offering exceptional
durability under high-pH mobile phase conditions. This column expands application flexibility while
maintaining the trusted performance of the Inertsil series.
Introduction & Key Features
Inertsil Hybrid-C18 is a silica-based reversed-phase column engineered with hybrid organic-inorganic bonding technology, enabling exceptional chemical stability across a broad pH range of 1–12.
● pH range 1–12 for both acidic and basic conditions
● Excellent batch-to-batch reproducibility
● Compatible with LC/MS, LC/MS/MS and high-pressure LC systems
● High durability and long lifetime, even under basic pH
● USP L1 classification (C18)
Specification
Base Material: High-pH Stable Hybrid Silica
Particle Size: 1.7 μm / 3.5 μm / 5 μm
Pore Size: 165 Å (16.5 nm)
Pore Volume: 1.00 mL/g
Surface Area: 185 m²/g
Carbon Loading: 15%
End-capping: Yes
USP Code: L1
Max Tempreture: 80°C (pH 1 - 10), 60°C (pH 1 - 12)
pH Range: 1 - 12
Max Pressure 1.7 μm: 18,000 psi (124 MPa) — PEEK hardware: 14,500 psi (100 MPa)
3.5 μm: 7,200 psi (50 MPa)
5 μm: 6,000 psi (40 MPa)
