20/10/2025
| What if integrating gene expression and WES data could uncover biomarkers driving immunotherapy resistance?
Here’s how Excelra turned complex genomic data into actionable biomarker insights: https://na2.hubs.ly/H01Fp9k0
We integrated Whole Exome Sequencing (WES) and gene expression profiles to identify biomarker signatures linked to immunotherapy efficacy and resistance in Small Cell and Renal Cell Carcinoma.
By combining somatic mutation data with transcriptomic insights using tools like Paradigm-shift, DriverNet, and DawnRank, key biological themes and pathway mechanisms were uncovered.
The outcome? validated biomarker signatures, network modules, and functional mutations that accelerate biomarker discovery and enable precision-driven immunotherapy research.