
02/08/2025
Plus {Vildagliptin/Metformin 50-850mg/50-1000mg} By Group, a European Pharmaceutical company based in Greece,
Vildagliptin and Metformin are two antidiabetic medications commonly used together in the management of type 2 diabetes mellitus. Here’s a clear and professional overview:
🔹 1. Vildagliptin
• Class: DPP-4 inhibitor (Dipeptidyl Peptidase-4 inhibitor)
• Mechanism of Action:
• Inhibits the enzyme DPP-4, which breaks down incretins (GLP-1 and GIP).
• By prolonging incretin activity, it increases insulin secretion in response to meals and reduces glucagon secretion.
• Effect: Lowers postprandial (after meal) blood glucose.
🔹 2. Metformin
• Class: Biguanide
• Mechanism of Action:
• Decreases hepatic glucose production (gluconeogenesis).
• Improves insulin sensitivity in peripheral tissues (muscle & fat).
• Slightly reduces intestinal glucose absorption.
• Effect: Lowers both fasting and postprandial blood glucose.
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