09/09/2023
https://youtu.be/zps7d0EavMg?si=Ckr9B_VnQnr478k_
I'm sorry to disappoint the enthusiasts of alcohol, those who advocate drinking it regularly and without restraint.
Drinking alcohol not only harms the vast majority of tissues and organs, increasing the risk of countless types of cancer, liver and cardiovascular diseases, and dementia, but new data also show that it causes serious dysfunction of the immune system and promotes inflammation.
Yes, a new study published in the prestigious journal Stem Cell Reports emphasizes that chronic alcohol consumption can damage the innate defenses of the immune system against microbes and exacerbate inflammatory responses in certain immune cells like monocytes and macrophages.
Using a model of voluntary ethanol consumption in primates, the researchers of this study observed an increase in the presence of monocytes in the blood and splenic macrophages with chronic alcohol intake. Furthermore, chronic alcohol consumption caused more intense inflammatory reactions when these cells were stimulated with LPS.
This study also suggests that the inflammation induced by alcohol consumption persists even after a one-month period of abstinence.
In summary, this study demonstrates that chronic alcohol consumption alters monopoiesis in the marrow compartment. Specifically, crucial immune cells CD14+ residing in the bone marrow exhibit transcriptional profiles skewed towards a pro-inflammatory state, indicating a restructuring of this tissue compartment due to chronic alcohol consumption.
In other words, chronic alcohol consumption disrupts monopoiesis by producing inflammatory monocytes similar to neutrophils.
In short, this study provides further evidence of the harmful effects of habitual alcohol consumption on human health. It's important to remember that chronic inflammation is one of the key factors contributing to accelerated aging and many common chronic pathologies.
I encourage each of you to reflect on the results of this new study and consider making adjustments to your behavior. After all, our health is our most invaluable asset!